Minimally Invasive Treatment of Hypertensive Basal Ganglia Hemorrhage by Transfrontal Keyhole Neuroendoscopy

  • End date
    Jul 1, 2023
  • participants needed
  • sponsor
    Peking University Third Hospital
Updated on 19 July 2021


To compare the prognosis of patients with hypertensive intracerebral hemorrhage treated by two different surgical methods, and to clarify the therapeutic effect of minimally invasive surgery, so as to find a better surgical method that can reduce surgical trauma and mortality and improve the prognosis of patients


In this study, a cohort observation method was adopted to observe a total of 52 patients who underwent two surgical procedures, namely, removal of hematoma in basal ganglo-region by keyhole neuroendoscopy under frontal ultrasound guidance and removal of hematoma by craniotomy microsurgery. They were divided into the endoscopic surgery group and the microsurgery group. In the endoscopic surgery group, 26 patients underwent removal of hematoma in basal ganglo-region by keyhole neuroendoscopy under frontal ultrasound guidance.In the microsurgery group, 26 cases were treated with craniotomy microsurgery for hematoma removal. The clearance rate of surgical hematoma, surgical safety, GCS score, GOS score, nerve fiber injury and postoperative complications were observed in the two groups 1 week, 1 month and 3 months after surgery.To observe and analyze whether endoscopic surgery group has advantages in improving hematoma clearance rate and efficacy

Condition Basal Ganglia Hemorrhage
Treatment Keyhole neuroendoscopic transfrontal ultrasound-guided hematoma removal, Small bone window craniotomy for hematoma removal under microscope
Clinical Study IdentifierNCT04958525
SponsorPeking University Third Hospital
Last Modified on19 July 2021


Yes No Not Sure

Inclusion Criteria

CT scan was used to diagnose cerebral hemorrhage in basal ganglia region. The amount of bleeding was 30-50ml, and no cerebral hernia was formed
Age between 30 and 70
The onset is longer than 24 hours and less than 72 hours
Informed consent of the patient and/or their relative

Exclusion Criteria

Brain injury, hemorrhage caused by intracranial aneurysm or cerebral arteriovenous malformation
Coagulation dysfunction
Insufficiency of vital organs of heart, liver, kidney or lung
Previous history of stroke with functional loss
Intracranial or systemic infection
Poor blood pressure control
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