Oral Administration of Tranexamic Acid in Anterior Cruciate Ligament Surgery Reduce Postoperative Haemarthrosis

  • End date
    Jul 1, 2023
  • participants needed
  • sponsor
    University of Liege
Updated on 8 August 2021


To find superiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss, haemarthrosis prevalence and improvement functional prognosis in anterior cruciate ligament arthroscopy.


Tranexamic acid is an anti-fibrinolytic drug, recommended in total hip arthroplasty to reduce peroperative and postoperative hemorrhagic complications. The original character of our study lies in the serum dosage of tranexamic acid, allowing to correlate the primary objective (blood loss) with this one. The investigators will focus on the reduction of the risks associated with the administration of intravenous medicines, the economic aspect and the ease of use.

Condition Exsanguination, Arthroscopy, Postoperative Hemorrhage, Anterior Cruciate Ligament Tear, Rupture of Anterior Cruciate Ligament, Anterior Cruciate Ligament Rupture, postoperative bleeding, postoperative blood loss
Treatment Placebo, Oral Tablet
Clinical Study IdentifierNCT04855877
SponsorUniversity of Liege
Last Modified on8 August 2021


Yes No Not Sure

Inclusion Criteria

Primary arthroscopic surgery for anterior cruciate ligament reconstruction

Exclusion Criteria

Renal failure with serum creatinine level higher than 1,40 mg/dL
Thromboembolic events in last 12 months before surgery
Congenital or acquired coagulation diseases
History of gastric surgery that could lead to malabsorption
Diabetic gastro-paresis
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