Effect of Vegan Diet and Lifestyle Changes on Indolent Lymphoma During Controlled Waiting Period

  • End date
    Oct 1, 2025
  • participants needed
  • sponsor
    Tel-Aviv Sourasky Medical Center
Updated on 20 July 2021


The aim of the present trial is to evaluate the effect of lifestyle changes on the natural history of indolent lymphomas, during the period of watchful waiting. The intervention program is comprised of specifically designed vegan nutrition, physical activity, mostly aerobic, and stress reduction by relaxation and meditation. Outcome results will be followed and analyzed for 3 years, taking into consideration the following parameters - disease burden, specific disease-related symptoms, relevant blood tests, body weight, indicators of well-being. Changes in these parameters will be correlated with the level of compliance and adherence to the intervention program. The results of the trial group of patients will be further compared to the natural history of the disease in a comparable group of patients during their waiting period who were not subject to the above intervention.

Condition Indolent Lymphoma
Treatment vegan diet and lifestyle changes
Clinical Study IdentifierNCT04957693
SponsorTel-Aviv Sourasky Medical Center
Last Modified on20 July 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years old
Patient sex - male and female
Diagnosis with indolent lymphoma in low-grade lymphoma (follicular lymphoma (FL), marginal zone lymphoma MZL), as assessed by Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria
Lack of need and non treatable patients at the time of diagnosis
Existence of detailed medical information about physical activity and dietary habits
Patients who have signed an informed consent form to participate in the study

Exclusion Criteria

Need for therapeutic intervention
Administration of chemotherapy and / or monoclonal antibodies or immunomodulatory preparation
Chronic inflammatory or infectious disease
Another malignant disease
Pregnant women, special populations - children and incapacitated of judgment
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