Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO

  • End date
    Jun 30, 2024
  • participants needed
  • sponsor
    Beijing Chao Yang Hospital
Updated on 16 July 2021


Unfractionated heparin is most common in the anticoagulation management of V-V ECMO. However, many side effects of unfractionated heparin, such as HIT, antithrombin deficiency, etc seriously affects the prognosis of patients. Argatroban is kind of direct thrombin inhibitors, which could be used used as an alternative anticoagulant of unfractionated heparin when HIT or antithrombin deficiency, etc. At present, there is no power enough evidence for the application of argatroban in V-V ECMO. This study aims to evaluat the safety and effectiveness of argatroban in the anticoagulation management of V-V ECMO compared with unfractionated heparin.

Condition Respiratory Failure
Treatment Unfractionated heparin, Argatroban
Clinical Study IdentifierNCT04925167
SponsorBeijing Chao Yang Hospital
Last Modified on16 July 2021


Yes No Not Sure

Inclusion Criteria

age older than 18 years old; received V-V ECMO because of sevever respiratory failure

Exclusion Criteria

anticoagulant contraindications; Confirmed or suspected, or previously diagnosed with heparin induced thrombocytopenia; Cerebral infarction or suspected patients; Patients with severe liver dysfunction; Allergic to heparin or argatroban; hemophilia; Unwilling or unable to complete the study
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