Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO
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- STATUS
- Recruiting
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- End date
- Jun 30, 2024
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- participants needed
- 174
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- sponsor
- Beijing Chao Yang Hospital
Summary
Unfractionated heparin is most common in the anticoagulation management of V-V ECMO. However, many side effects of unfractionated heparin, such as HIT, antithrombin deficiency, etc seriously affects the prognosis of patients. Argatroban is kind of direct thrombin inhibitors, which could be used used as an alternative anticoagulant of unfractionated heparin when HIT or antithrombin deficiency, etc. At present, there is no power enough evidence for the application of argatroban in V-V ECMO. This study aims to evaluat the safety and effectiveness of argatroban in the anticoagulation management of V-V ECMO compared with unfractionated heparin.
Details
| Condition | Respiratory Failure |
|---|---|
| Treatment | Unfractionated heparin, Argatroban |
| Clinical Study Identifier | NCT04925167 |
| Sponsor | Beijing Chao Yang Hospital |
| Last Modified on | 16 July 2021 |
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