Diagnostic and Prognostic Value of Cardiac Biomarkers for Early Coronary Bypass Occlusion in Patients Undergoing Coronary Revascularization

  • STATUS
    Recruiting
  • days left to enroll
    42
  • participants needed
    480
  • sponsor
    University Hospital, Basel, Switzerland
Updated on 16 July 2021

Summary

This study is to evaluate the correlation between hs-cTn level as cardiac biomarker for ischemia and early graft occlusion as assessed by CCT in patients undergoing coronary bypass surgery.

Description

The early diagnosis of the periprocedural myocardial infarction (MI) due to the bypass graft occlusion is an important element, in order to introduce early therapeutic strategies. Invasive coronary angiography (CA) is the gold standard to evaluate the postoperative myocardial ischemia due to the graft occlusion. Since this procedure has several important risks, such as thromboembolic events, dissection, bleeding, and contrast dye-induced nephropathy, in daily clinical practice, only patients with strong clinical suspicion of early MI following coronary artery bypass grafting (CABG) undergo this invasive procedure. There is a clinical need for the development of safe and accurate non-invasive diagnostic approaches to assess the early coronary bypass graft occlusion and to predict the consequent MI. A new clinical approach for the identification of the early post-procedural graft occlusion in patients undergoing CABG surgery is the high-sensitivity cardiac troponin (hs-cTn) cut-off level. The peri-operative bypass occlusion will be assessed by a Coronary Computed Tomography (CCT) scan which is a widely available non-invasive approach that permits an accurate evaluation of coronary stenosis. This study is to evaluate the correlation between hs-cTn level as cardiac biomarker for ischemia and early graft occlusion as assessed by CCT in patients undergoing coronary bypass surgery.

Details
Condition Coronary Bypass Graft Occlusion
Treatment data collection from the hospital records
Clinical Study IdentifierNCT04595630
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on16 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with isolated coronary bypass surgery

Exclusion Criteria

Patients withholding or lacking informed consent
Patients requiring a concomitant procedure
Exclusion criteria concerning the CCT scan
Patients with known allergy to iodine-containing contrast agents
Renal function impairment (serum creatinine >140 mmol/l; estimated glomerular filtration rate (GFR) <30 ml/min/1.73 m2)
Pregnancy
Unstable clinical state or severe heart failure
Patients with registered MI and registered bypass occlusion in coronary angiogram
Patients that didn't undergo a CCT prior to discharge
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