The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy

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    Chang Gung Memorial Hospital
Updated on 4 October 2022


By using subjective and objective measurements, the investigators monitore the change of circadian rhythm in Intensive Care Unit (ICU) patients with acute myocardial infarction and the effect of light therapy.


The investigators include 70 patients who are admitted to coronary care unit due to coronary artery disease, with severity between Killip II-III and age between 40-75. Participants are randomly assigned to 2 groups, the experimental group (blue light) and the placebo group (white light). Both groups receive light therapy or white light daily between 8am to 12pm. The investigators use actigraphy and heart rate variation analysis, and check melatonin level as objective measurements. The investigators use delirium scales to evaluate delirium and its severity. The light therapy is stopped once a participant is diagnosed of delirium or transferred, and the investigators keep following participants until discharge to evaluate the prognosis.

Condition Delirium, Circadian Dysrhythmia
Treatment Blue light therapy, White light
Clinical Study IdentifierNCT04953767
SponsorChang Gung Memorial Hospital
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis for admission is acute myocardial infarction with severity between Killip II III
Age is between 40-75
Participants who are willing to participate in the study and sign the informed consent

Exclusion Criteria

Using sedative hypnotic drugs
Blindness or severe cataract
Neurological diseases such as epilepsy, brain injury, or stroke
Severe mental disorder such as major depressive disorder, bipolar disorder, schizophrenia, intellectual disability or substance use disorders
Unable to communicate
Participants who are unwilling to participate in the study or refuse to sign the informed consent
Participants who are not suitable to include in this study, evaluate by PI or Co-PI
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