Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

  • STATUS
    Recruiting
  • End date
    May 1, 2022
  • participants needed
    5
  • sponsor
    Centre Hospitalier Universitaire de Nīmes
Updated on 19 July 2021
weakness
plasma exchange
polyneuropathy
igiv

Summary

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

Details
Condition Chronic inflammatory demyelinating polyradiculoneuropathy, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Treatment blood sampling
Clinical Study IdentifierNCT04742374
SponsorCentre Hospitalier Universitaire de Nīmes
Last Modified on19 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months
Patients who have given free written informed consent
Patients who have signed the consent form
Patients affiliated to or beneficiaries of a health insurance scheme
Adult patients (18 ans)

Exclusion Criteria

Patients Under the age of 18
Patients under immunosuppressive treatment for less than 3 months
Patients participating in Category 1 research involving human subjects
Patients in an exclusion period determined by another study
Patients under legal protection, guardianship or curatorship
Patients unable to express consent
Patients for whom it is impossible to give informed information
Pregnant, parturient or breastfeeding patients
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