A Study to Investigate the Regional Brain Kinetics of the Positron Emission Tomography Ligand [18F]-JNJ-70099731 in Healthy Male Participants

  • participants needed
  • sponsor
    Janssen Research & Development, LLC
Updated on 5 December 2021
Accepts healthy volunteers


The purposes of this study are to measure the whole-body distribution and radiation dosimetry of [18F]-JNJ-70099731 (Part A), to measure the uptake, distribution, and clearance (CL) of [18F]-JNJ-70099731 by Positron Emission Tomography (PET) and to model tissue specific kinetics of [18F]-JNJ-70099731 with the appropriate input function (IF) (Part B), and to measure participant test-retest variability in the distribution of [18F]-JNJ-70099731 by comparing PET scans obtained at least 1 week apart (Part C) in the brain of healthy male participants.

Condition healthy
Treatment [18F]-JNJ-70099731
Clinical Study IdentifierNCT04911543
SponsorJanssen Research & Development, LLC
Last Modified on5 December 2021

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