B-cell Chronic Lymphoid Malignancies Markers

  • STATUS
    Recruiting
  • End date
    Mar 30, 2023
  • participants needed
    420
  • sponsor
    University Hospital, Strasbourg, France
Updated on 18 July 2021
lymphoma
flow cytometry
marginal zone lymphoma

Summary

Lymphoid chronic B-cell malignancies are frequent pathologies that affect adults, with a very variable prognosis and treatment (some of them can remain untreated). The diagnosis of these malignancies relies on the study of the morphology of tumoral cells and the expression by these cells of several markers, mainly via a technical approach called flow cytometry. Because the markers currently used remain imperfect, additional ones are needed for an accurate diagnosis that affect both prognosis and treatment.

In addition, because numerous markers are used at the diagnosis, there is a need of tools that synthetize the multi-dimensional structure of the data obtained.

The primary purpose of this study is to detect new markers that can be of help for the diagnosis of Marginal Zone Lymphoma and other B-cell chronic lymphoid malignancies.

The secondary purpose of this study is to obtain a statistical algorithm that allow a good prediction of the different sub-types of chronic B-cell malignancies mainly using the results of flow cytometry.

Details
Condition Mantle cell lymphoma, MALT Lymphoma, leukemia chronic lymphocytic, Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia, Follicular Lymphoma, Non-Hodgkin's Lymphoma, Hairy Cell Leukemia, small lymphocytic lymphoma, Lymphocytic Leukemia, Chronic, Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, chronic lymphocytic leukemia (cll)
Clinical Study IdentifierNCT04952974
SponsorUniversity Hospital, Strasbourg, France
Last Modified on18 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients over 18 years-old with of Marginal Zone Lymphoma and other B-cell chronic lymphoid malignancies
patients that gave their informed consent for the conservation of blood or bone marrow cells (primary objective 1)
patients that gave their informed consent for the retrospective use of their clinical and biological data

Exclusion Criteria

patients under guardianship or curatorship
patients who did not gave their consent for the use of their cells and/or data
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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