A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence

  • End date
    Oct 23, 2022
  • participants needed
  • sponsor
Updated on 24 September 2021
AbbVie_Call Center
Primary Contact
Dr. Shannon Humphrey Inc. /ID# 229522 (1.3 mi away) Contact
+30 other location


The purpose of the study is to evaluate the safety and effects of onabotulinumtoxinA (BOTOX) for the temporary improvement in the appearance of platysma prominence.

Study doctors will randomize participants into 1 of the 2 groups, called treatment arms. There is a 1 in 2 chance that a participant will be assigned to placebo. Around 400 participants will be enrolled in the study in the United States and Canada.

Participants will receive either intramuscular injections of onabotulinumtoxinA (BOTOX) or placebo.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular monthly visits during the study at the study site.

Condition Platysma Prominence
Treatment Placebo, OnabotulinumtoxinA
Clinical Study IdentifierNCT04949399
Last Modified on24 September 2021


Yes No Not Sure

Inclusion Criteria

Participants must voluntarily sign and date an informed consent, approved by
an independent ethics committee (IEC)/institutional review board (IRB), prior
to the initiation of any screening or study specific procedures
Are willing and able to comply with procedures required in the protocol
Adult male or female, at least 18 years old at the time of signing the
informed consent
Good health as determined by medical history, physical examination, vital
signs, and investigator's judgment

Exclusion Criteria

Any medical condition that may put the participant at increased medical risk
with exposure to BOTOX, including diagnosed myasthenia gravis, Eaton-Lambert
syndrome, amyotrophic lateral sclerosis, or any other condition that might
interfere with neuromuscular function
Participant has an anticipated need for treatment with botulinum toxin of any
serotype for any indication during the study (other than study intervention)
Anticipated need for surgery or overnight hospitalization during the study
Females who are pregnant or breastfeeding and are considering becoming
pregnant or donating eggs during the study
Known immunization or hypersensitivity to any botulinum toxin serotype
History of clinically significant (per investigator's judgment) drug or
alcohol abuse within the last 6 months
Lower facial and neck hair, scarring (e.g., acne), or other abnormal
variations that may interfere with photography (such that photograph is not
Tattoos, jewelry, or clothing that cannot be removed, and that obscure the
target area of interest
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note