VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma)

  • STATUS
    Recruiting
  • End date
    Jan 2, 2025
  • participants needed
    170
  • sponsor
    Novartis Pharmaceuticals
Updated on 10 April 2022
lymphoma
multiple myeloma
leukemia
refractory acute myeloid leukemia (aml)
tumor cells
b-cell lymphoma
refractory multiple myeloma
refractory non-hodgkin's lymphoma

Summary

The purpose of the study is to identify doses and schedules of VOB560 and MIK665 that can be safely given and to learn if the combination can have possible benefits for patients with Non-Hodgkin lymphoma (NHL), Multiple Myeloma (MM) or Acute Myeloid Leukemia (AML).

VOB560 and MIK665 are selective and potent blockers respectively of the B-cell lymphoma 2 (BCL2) protein and of the myeloid cell leukaemia 1 (MCL1) protein, proteins that may protect tumor cells from undergoing cell death. VOB560 and MIK665 are designed to block the functions of the BCL2 and MCL1 proteins, so that the tumor cells that rely on these proteins undergo cell death.

Preclinical data suggest that concomitant treatment with VOB560 in combination with MIK665 induces robust anti-tumor activity.

Details
Condition Non-Hodgkin Lymphoma (NHL), Acute Myeloid Leukemia (AML), Multiple Myeloma (MM)
Treatment MIK665, VOB560
Clinical Study IdentifierNCT04702425
SponsorNovartis Pharmaceuticals
Last Modified on10 April 2022

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