A Phase 2a, Open-Label Study to Evaluate the Safety and Efficacy of Selgantolimod (SLGN)-Containing Combination Therapies for the Treatment of Chronic Hepatitis B (CHB)

  • End date
    Apr 28, 2024
  • participants needed
  • sponsor
    Gilead Sciences
Updated on 28 October 2022


The primary objectives of this study are to evaluate the safety and tolerability of study treatment(s) (selgantolimod-containing combination therapies) and to evaluate the efficacy of study treatment(s) as measured by the proportion of participants who achieve functional cure, defined as hepatitis B surface antigen (HBsAg) loss and hepatitis B virus (HBV)deoxyribonucleic acid (DNA) < lower limit of quantitation (LLOQ) at Follow-up (FU) Week 24 in participants with chronic hepatitis B (CHB).

Condition Chronic Hepatitis B
Treatment Nivolumab, Tenofovir alafenamide, VIR-2218, Selgantolimod
Clinical Study IdentifierNCT04891770
SponsorGilead Sciences
Last Modified on28 October 2022


Yes No Not Sure

Inclusion Criteria

Willing and able to provide informed consent
Chronic HBV infection for at least 6 months
Willing to follow protocol-specified contraception requirement

Exclusion Criteria

Have extensive fibrosis or cirrhosis in the liver
Have or had liver cancer (hepatocellular carcinoma)
Have an autoimmune disease
Have chronic liver disease other than HBV
Females who are breastfeeding, pregnant, or who wish to become pregnant during the study
Note: Other protocol defined Inclusion/Exclusion criteria may apply
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