This research study is studying to see whether bevacizumab may treat chronic bleeding and
iron deficiency anemia in Hereditary Hemorrhagic Telangiectasia (HHT).
Hereditary Hemorrhagic Telangiectasia (HHT) is a disorder that causes abnormal blood vessel
formation. In HHT, there is a mutation in the TGF- pathway, which results in an increase of
vascular endothelial growth factor (VEGF) levels. An increase in VEGF levels can result in
poorly formed blood vessels that have a higher rate of bleeding than normal blood vessels.
Bevacizumab is designed to block VEGF activity. It is believed that targeting increased VEGF
levels may be able to treat HHT.
This research study involves the following study drug:
In this research study, the investigators are studying the study drug, bevacizumab.
Researchers would like to see whether bevacizumab effectively treats Hereditary Hemorrhagic
Telangiectasia (HHT) and what side effects occur.
The research study procedures include: screening for eligibility, pretreatment period,
study treatment, end-of-study visit, and follow-up visit.
Participants will be observed for 12 weeks and then receive study treatment for 24 weeks
and will be followed for 30 days after ending study treatment.
This research study involves the following study drug: Bevacizumab
It is expected that about 20 people will take part in this research study.
This research study is a Phase II clinical trial. Phase II clinical trials test the safety
and effectiveness of an investigational drug to learn whether the drug works in treating
Hereditary Hemorrhagic Telangiectasia (HHT). "Investigational" means that the drug is being
The U.S. Food and Drug Administration (FDA) has not approved bevacizumab for Hereditary
Hemorrhagic Telangiectasia (HHT), but it has been approved for other uses.
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.