The Application of Glucose CEST MR Imaging in Brain Tumor

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    100
  • sponsor
    Zhujiang Hospital
Updated on 7 August 2021

Summary

Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Our study try to evaluate the feasibility of dynamic glucose enhanced(DGE) magnetic resonance imagingMRIin brain tumor, which based on D-glucose weighted chemical exchange saturation transfer (gluceoCEST).

Description

methods Brain tumor patients were recruited. Time-resolved glucose signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic glucose enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of D-glucose. During the dynamic glucose scan, a brief hyperglycemic state was established by intravenous infusion of hospital-grade D50 glucose (D50, 25 g of dextrose in 50 mL of water sterile solution), followed by 20 mL of saline solution in 1 arm. The glucose infusion was performed using a power injector at an infusion rate of 0.2 mL/s, corresponding to total infusion times of 250 seconds. Performing contrast enhancement based on Gd-DTPA in 30 minutes later, which was used for comparison as golden standard.

The area of hyperintensity will be measured, which represents the area of brain tumor.

Differential test and Consistency analysis were used for statistical analysis.

Details
Condition Magnetic Resonance Imaging
Treatment d-glucose
Clinical Study IdentifierNCT04945499
SponsorZhujiang Hospital
Last Modified on7 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient must have a brain mass consistent with a primary brain tumor or metastatic brain tumor
able to give consent and willingness to participate in this study

Exclusion Criteria

presence of any ferromagnetic implant (cardiac pacemakers, aneurysm clip, etc.)
pregnancy
claustrophobia or anxiety disorder
history of vertigo
persons with diabetes mellitus (self-report or HbA1C >= 6.5%)
Sickle cell disease
persons taking prescription medicine for hypertension
blood iron deficiency (Hb concentration < 11 g/dL or Hct < 32%)
If volunteering for MRI: history of kidney disease and/or eGFR < 60\
Middle-ear disorder
double vision
Seizure disorder
Multiple myeloma
Solid organ transplant
History of severe hepatic disease/liver transplant/pending liver transplant
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