Cardiorespiratory Fitness in Children and Adolescents After Cancer Treatment.

  • End date
    Dec 3, 2025
  • participants needed
  • sponsor
    Universität Duisburg-Essen
Updated on 3 September 2021


The POWER-study is a two-arm exercise intervention study for pediatric patients following acute cancer treatment. This clinical trial will investigate the effects of a 12-week moderate to high-intensity exercise program on cardiorespiratory fitness in children and adolescents beginning 6 weeks after completion of acute cancer treatment.


The main objective of the POWER study is to investigate the effects of a 12-week moderate to high-intensity, partially supervised exercise program on cardiorespiratory fitness (VO2peak) in children and adolescents who have completed acute cancer treatment. This randomized controlled trial will include n=56 patients. Patients will be randomly assigned to the intervention or the control group. Patients in the intervention group will perform two supervised exercise sessions per week, one personal training session and one group-based training session. During an initial consultation, both groups receive recommendations for individual physical activity goals and a brochure with exercise recommendations as well as a fitness tracker to monitor their daily physical activity. Only the intervention group will receive daily activity targets, which will be adjusted on a regular basis. The study starts 6 weeks after completion of the patient's acute cancer treatment.

Secondary aims of this interventional study are to evaluate additional performance markers, including muscle strength, functional mobility, balance, body composition and patient-reported outcomes including QoL, fatigue, and cognitive function as well as blood markers to evaluate changes in metabolic, immune, and heart health.

Condition All Types of Pediatric Cancer
Treatment Experimental: moderate to high-intensity exercise
Clinical Study IdentifierNCT04765020
SponsorUniversität Duisburg-Essen
Last Modified on3 September 2021


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Inclusion Criteria

Children and adolescents between 7 and 23 years of age
Completion of acute cancer treatment and receiving follow-up care in Krefeld (Helios Hospital Krefeld)
weeks post cancer-treatment
Signed informed consent (Parents and Patient)

Exclusion Criteria

<7 years of age, >23 years of age
Medical condition that limits participation in one of the study arms
Inability to follow the training-protocol
Inability to carry out the spiroergometry on a cycle ergometer
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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