Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment

  • STATUS
    Recruiting
  • End date
    Apr 30, 2023
  • participants needed
    484
  • sponsor
    Wen-hong Zhang
Updated on 9 July 2021
fever
lethargy
encephalitis

Summary

Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways. Therefore, we conducted this multicenter, prospective, and randomized controlled study. It was designed to evaluate the diagnostic performance and its impact on the outcomes of the patients enrolled. As such, we came to the results of the optimal process of diagnosis and treatment strategy of encephalitis/meningeal syndromes with improved effective treatments.

Details
Condition Polymerase Chain Reaction, Next Generation Sequencing, meningitides, pcr analysis, Meningitis, PCR test, Meningoencephalitis, Encephalitis, brain inflammation, inflammation of the brain
Treatment Types of etiological diagnostic methods
Clinical Study IdentifierNCT04946682
SponsorWen-hong Zhang
Last Modified on9 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with suspected meningitis : the patient has a new fever (>38.5), accompanied by 1 of the following manifestations
Stiff neck
Change in state of consciousness
Other signs of meningitis: such as meningeal irritation
Patients with suspected encephalitis: Unexplained changes in the state of consciousness for more than 24 hours (including lethargy, agitation, personality changes, etc.) or accompanied by recent memory impairment, with the following 1
manifestations
Fever during the course of the disease ( 38); (oral temperature)
Convulsions or focal neurological symptoms
Increase in the number of cerebrospinal fluid cells (>410^6/L)
Abnormal EEG that meets the manifestations of encephalitis and cannot be attributed to other reasons
Imaging suggests encephalitis (CT or MRI)
Have not received effective anti-infective treatment yet
Have an identifiable address and live in the area during treatment
Suspected encephalitis/meningitis patients who are willing to participate in trial treatment and follow-up and can give informed consent (if the subject is illiterate, sign or hearing consent is required)
Willing to comply with follow-up research procedures

Exclusion Criteria

Known breastfeeding or pregnancy
Failure to comply with treatment or follow-up time
The researcher believes that there are any conditions (social or medical) that allow subjects to participate in unsafe
Participating in other clinical studies
Insufficient cerebrospinal fluid or blood samples
Clinically diagnosed infections, tumors or other neurological diseases
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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