Comprehensive Swallowing Rehabilitation in Patients With MSA

  • End date
    Jun 30, 2022
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 13 September 2021


The purpose of this study is to investigate the effect of comprehensive swallowing rehabilitation in patients with multiple system atrophy.


Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease characterized by parkinsonism, cerebellar syndrome, and autonomic failure. Dysphagia is a clinically significant symptom leading to pneumonia that causes death in patients with MSA. Although the symptoms of dysphagia in the two subtypes of MSA-the parkinsonian variant and the cerebellar variant- are different, there is no significant difference in the latency to onset of tube feeding. Therefore, effective intervention is needed to improve the safety and efficiency of swallowing regardless of the subtypes of MSA.

Although swallowing rehabilitation has been widely applied for swallowing disorders in patients with MSA, few studies have reported the clinical effect of applying swallowing therapy. Comprehensive swallowing rehabilitation has focused on functional muscle training, compensatory swallowing maneuvers, and thermal-tactile stimulation, which is used to treat dysphagia from stroke, Parkinson's disease, and head and neck cancer. Therefore, this study aims to investigate the effect of comprehensive swallowing rehabilitation in patients with MSA.

Condition Multiple System Atrophy, Shy-Drager Syndrome
Treatment Comprehensive swallowing rehabilitation, Swallowing education
Clinical Study IdentifierNCT04782284
SponsorSeoul National University Hospital
Last Modified on13 September 2021


Yes No Not Sure

Inclusion Criteria

Age >19 years
Clinically diagnosed with MSA according to the guidelines of the 2nd consensus of the Gilman criteria
Clinically diagnosed to have dysphagia by a physiatrist
Two or more points on the Penetration-aspiration scale (PAS) from the Videofluoroscopic swallowing study (VFSS) conducted within 3 months

Exclusion Criteria

Moderate to severe cognitive dysfunction with Mini-mental State Examination score < 19
Comorbidities or structural abnormalities that may affect swallowing function
Other comorbidities that make it difficult to participate in the study
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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