Total-body 13N-NH3 PET/CT to Study the Blood Perfusion in Whole Body

  • STATUS
    Recruiting
  • participants needed
    16
  • sponsor
    RenJi Hospital
Updated on 28 January 2023
Accepts healthy volunteers

Summary

The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs caused by the decreased EF value or aortic stenosis.

Description

Participants are invited to participate in a research that seeks to understand the dynamic blood perfusion in human body. The investigators expect to have sixteen participants in this study at Renji Hospital, Shanghai. About four of the participants will be patients who have been diagnosed with decreased ejection fraction(EF) value, three participants will be healthy individuals with no known vascular disease, and about 9 patients will be patients with aortic stenosis. These healthy subjects will allow researchers to compare blood perfusion difference with those of persons with decreased EF value or aortic stenosis. All the participants will undergo the same procedure.

If participants agree to participate in this study, researchers will first interview participants and review the past medical record in order to document the medical history. When the screening procedures confirm that participants are eligible to participate in the study, participants will receive one dose of the non-therapeutic administration of a radioactive tracer called N-13 ammonia(13NH3) , then undergo one total body 13NH3 PET/CT Scan (uEXPLORER) to determine the blood flow value of the brain, kidney and other organs. The total body 13NH3 PET/CT Scan will allow investigators to observe and analyze the real-time blood flow differences between patients with between healthy controls and decreased EF value or aortic stenosis.

Details
Condition Decreased cardiac output, Cardiac Output
Treatment total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)
Clinical Study IdentifierNCT04941248
SponsorRenJi Hospital
Last Modified on28 January 2023

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