Laparoscopic or Abdominal Radical Hysterectomy for Cervical Cancer(Stage IB3 IIA2)

  • End date
    Jun 20, 2026
  • participants needed
  • sponsor
    Obstetrics & Gynecology Hospital of Fudan University
Updated on 20 November 2021
pet/ct scan


The purpose of this study is to confirm whether there is a difference between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in patient survival for Cervical Cancer (Stage IB3, IIA2).


The purpose of this study is to compare LRH (or robotic-assisted) and ARH in patients with cervical cancer (Stage IB3, IIA2), by a multicenter stratified randomized controlled study, mainly including the following aspects:

  1. To compare the differences in PFS and OS between patients receiving LRH and ARH.
  2. To investigate whether PFS and OS in LRH can be improved by more rigorous specification of surgical details (including tumor-free principles and standard surgical scopes).
  3. To assess postoperative complications and quality of survival.

Condition carcinoma of cervix, carcinoma of the cervix, Cervical Cancer, cervical carcinoma, Disorders of cervix NOS, carcinoma of the cervix uteri, cervix cancer, Uterine Serous Carcinoma, cancer of the cervix, cervical cancer, uterine, Uterine Cancer
Treatment Total Abdominal Radical Hysterectomy, Total Laparoscopic or Robotic Radical Hysterectomy
Clinical Study IdentifierNCT04939831
SponsorObstetrics & Gynecology Hospital of Fudan University
Last Modified on20 November 2021


Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of squamous carcinoma of the cervix, adenocarcinoma, squamous adenocarcinoma (Stage IB3,IIA2)
Age 21 years and 70 years
Surgery type B and C (refer to Q-M surgical staging)
Normal range of liver and kidney function and blood count (specific details below) Hemoglobin > 60g/L Platelets > 70 _109/L Leukocytes > 3_109/L Creatinine < 50mg/dL Transaminase abnormal indicators 3 Maximum value of transaminases not exceeding 3 times the corresponding normal value
No history of other malignancies
Physical strength classification: Karnofsky score 60
Subjects voluntarily joined the study, signed the informed consent form, were compliant and cooperated with the follow-up
No psychiatric disorders and other serious immune system disorders (e.g. lupus erythematosus, myasthenia gravis, HIV infection, etc.) (Note: Maximum diameter measurement of cervical lesions is based on PET-CT, or CT, or MRI)

Exclusion Criteria

Those who are contraindicated for various surgeries and cannot undergo surgery
Patients who have received pelvic/abdominal radiotherapy irradiation or neoadjuvant chemotherapy for cervical cancer
Patients with recurrent cervical cancer
Patients with CT, MRI or PET-CT suggesting suspicious metastasis of pelvic lymph nodes with maximum diameter >2cm after further improvement of preoperative examination
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