The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI

  • days left to enroll
  • participants needed
  • sponsor
    Emory University
Updated on 4 October 2022
computed tomography angiography
perfusion imaging
exercise stress test
coronary ct
myocardial perfusion imaging


The overall goal of this project is to compare the absolute quantification of myocardial perfusion done by using CT myocardial perfusion imaging (CT-MPI) and the coronary flow measured by using CT Fractional Flow Reserve analysis (CT-FFR) to the gold standard represented by PET myocardial perfusion imaging (PET-MPI).


Participants will be patients who are scheduled to undergo PET Myocardial Perfusion Imaging, which is the traditional method for evaluating patients with suspected blockages or narrowing of the heart vessels (coronary artery disease) causing impaired blood to flow to the heart muscle (myocardium).

The purpose of the study is to determine and compare the newest heart imaging equipment which allows the non-invasive evaluation of coronary anatomy, coronary flow and myocardial perfusion in patients with suspected or proven coronary artery disease (CAD) with the actual gold-standard for quantitative myocardial perfusion assessment. In order to achieve this aim, the study team will compare heart scan results from a computed tomography (CT) Myocardial Perfusion Imaging (CT-MPI) scan and CT-Fractional Flow Reserve (FFR) with the actual standard clinical care represented by a PET Myocardial Perfusion Imaging (PET-MPI) study.

Condition Coronary Artery Disease
Treatment Regadenoson, CT-FFR, PET-MPI Protocol, CT-MPI
Clinical Study IdentifierNCT04316676
SponsorEmory University
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Referred for a clinically indicated CT-MPI for CAD assessment
Must provide written informed consent prior to any study-related procedures being performed
Must be willing to comply with all clinical study procedures

Exclusion Criteria

Pregnant or nursing females. The possibility of pregnancy will be excluded by testing (serum or urine ßHCG) within 24 hours before study agent administration, or if the woman has previous surgical sterilization, or if the woman is post menopausal, with minimum one (1) year history without menses
Currently taking or has taken within 48 hours the following excluded medications
ActoPlus Met (Pioglitazone + metformin)
Avandamet (Rosiglitazone + metformin)
Fortamet (metformin)
Glucovance (Glyburide +metformin)
Glucophage (metformin)
Glucophage extended-release (XR) (metformin)
Glumetza (metformin)
Janumet (Sitagliptin + metformin)
Metaglip (Glipizide + metformin)
Riomet (metformin)
Implanted rhythm devices (pacemaker, defibrillator)
Acute psychiatric disorder
Unwilling to comply with the requirements of the protocol
Previously entered this study
Known hypersensitivity to iodinated contrast material, beta-blockers, or pharmaceutical stressors used in this study
Suffers from claustrophobia
Impaired renal function (GFR < 45 ml/min)
Acute hypotension (<100 mm Hg systolic)
nd or 3rd degree atrioventricular (AV) block
Clear my responses

How to participate?

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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