Physiologic Changes of Posterior Ocular Segment During the Menstrual Cycle

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Khon Kaen University
Updated on 12 September 2021


Changes of luteinizing hormone (LH), estrogen and progesterone during the menstrual cycle influence the ocular physiology in both anterior and posterior segments. From the literature review, there were no significant differentiation in tear physiology, anterior chamber dept, lens thickness and refractive status. Some studies demonstrated then the central corneal thickness was thinner in the follicular phase, but this is non-conclusive. Advance in ophthalmic technologies provide few studies of posterior segment changes during the menstrual cycle, however, there were quite difference in methodology such as detection methods of ovulation.


There were 2 studies of posterior segment changes during the menstrual cycle. Akar et al showed significant decrease of neuroretinal rim area and increase of cupt area in late luteal phase. Ulas et al found that choroidal thickness was significant thicker in mid-luteal phase. However, the study of retinal vascular density by optical coherence tomography angiography (OCTA) during the menstrual cycle has never been published before.

Condition Retinal Vascular
Treatment Optovue®
Clinical Study IdentifierNCT04731207
SponsorKhon Kaen University
Last Modified on12 September 2021

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