A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis (ASPEN)

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Updated on 2 August 2021


This study will investigate the efficacy, safety, and tolerability of brensocatib in the clinical management of subjects with Non-Cystic Fibrous Bronchiectasis (NCFBE).

Subjects will be randomized in a 1:1:1 ratio to 3 treatment arms to receive brensocatib 10 mg once daily (QD), brensocatib 25 mg QD, or matching placebo QD for 52 weeks.

The goals are to confirm the findings from the phase two study, INS1007-201 and, if successful, to support marketing authorizations for brensocatib for the treatment of adult patients with NCFBE.


  • Condition: Non-Cystic Fibrous Bronchiectasis (NCFBE)
  • Drug: Brensocatib 
  • Clinical Trial Identifier: NCT04594369
  • Sponsor: Insmed Incorporated 

Condition Pulmonary Fibrosis
Clinical Study IdentifierTX276502
Last Modified on2 August 2021

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