A Study to Evaluate CBP-201 in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

  • STATUS
    Recruiting
  • End date
    Jan 27, 2023
  • participants needed
    147
  • sponsor
    Suzhou Connect Biopharmaceuticals, Ltd.
Updated on 27 September 2021
Investigator
Malinda Longphre, PhD
Primary Contact
Connect Investigative Site 301 (1.8 mi away) Contact
+50 other location

Summary

This study will evaluate the effect of CBP-201 in adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).

Description

This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of CBP-201 on a background of mometasone furoate nasal spray (MFNS) in reducing endoscopic nasal polyp score (NPS) and nasal congestion/obstruction score (NCS) severity in eligible patients with CRSwNP whose disease remains inadequately controlled despite daily treatment with intranasal corticosteroid (INCS) therapy in comparison to placebo. CBP-201 is administered as a subcutaneous (SC) injection. The study is divided into a treatment period of 24 weeks and a follow-up period of 8 weeks.

Details
Condition Chronic Rhinosinusitis With Nasal Polyps
Treatment Placebo, CBP-201
Clinical Study IdentifierNCT04783389
SponsorSuzhou Connect Biopharmaceuticals, Ltd.
Last Modified on27 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Female and male patients aged 18 and 75 years at the time of screening
Patients who are diagnosed with chronic rhinosinusitis with bilateral polyps despite treatment with systemic corticosteroid within the past 2 years and/or medical contraindication/intolerance to systemic corticosteroids. The polyps have a minimum bilateral NPS of 5 out of a maximum score of 8 with at least a score of 2 for each nostril at screening and baseline evaluated by endoscopy
Nasal congestion/blockade/obstruction with moderate or severe symptom severity (Nasal Congestion Score of > 2) at screening and a weekly average severity of > 1 at time of randomization
Patients using a documented stable dose of nasal mometasone at least 200 mcg/day, or an equivalent daily dose of another INCS, for at least 28 days before randomization and willing to continue the dose for the duration of the study. Note: For patients who are using an alternative INCS product other than mometasone furoate nasal spray (MFNS) prior to the screening visit, the investigator must switch the patient to MFNS at V1
Patients willing to enter Patient Diary daily symptom assessments and maintain stable dosing with MFNS with a compliance of at least 70% in the 7 days preceding randomization. Note: Patients must use nasal mometasone at least 200 mcg/day, or equivalent, for at least 28 days before randomization, which can include days prior to screening with supportive documentation. Run-in can be 7-31 days with the compliance determined in the week prior to dosing
Male patients who are non-sterilized and sexually active with a female partner of childbearing potential agree to use highly effective contraception from randomization until 8 weeks after last dose
Female patients of childbearing potential who are sexually active with a nonsterilized male partner should have a confirmed negative serum beta-human chorionic gonadotropin test at Visit 1 and agrees to use highly effective contraception from signing of informed consent throughout the duration of the study and for 8 weeks after last dose
Patient is able to understand and willing to sign the informed consent form (ICF) prior to any study related procedures being performed
Willing and able to comply with all study visits and study-related procedures, in the opinion of the Investigator

Exclusion Criteria

\-
A patient who meets any of the following criteria will be ineligible to
participate in this study
\. Patients unable to use MFNS
\. Patients who are taking or have taken the following prohibited therapies
as specified
Systemic steroids within 28 days prior to screening
Other nonbiologic investigational drugs within 60 days (or 5 half-lives, whichever is longer) of screening
Intranasal corticosteroid drops or corticosteroid-administering devices (eg, OptiNose device or stents) within 28 days prior to screening
Non-steroidal immunosuppressants (eg, cyclosporine, methotrexate, azathioprine, mycophenolate, sirolimus, tacrolimus) within 60 days or 5 half-lives, whichever is longer, of screening
Any monoclonal antibody therapy (eg, benralizumab, mepolizumab, omalizumab, resilizumab, dupilumab) or investigational biologic drug for asthma or other diseases within 60 days or 5 half-lives, whichever is longer, of screening
Leukotriene antagonists/modifiers within 7 days prior to screening for patients who were not on continuous treatment for 30 days prior to screening
Allergen immunotherapy for patients who were not on maintenance treatment for at least 90 days prior to screening
Patients who did not respond favorably to previous dupilumab treatment (eg, therapy failure or patient experienced an adverse reaction to treatment)
Patients who have undergone any nasal surgery (including polypectomy) within 6 months before screening; or have a history of sinus or nasal surgery modifying the structure of the nose such that assessment of NPS is not possible, or have had uncontrolled epistaxis requiring surgical or procedural intervention, including nasal packing
Patients with conditions/concomitant diseases making them non evaluable at screening or for the primary efficacy endpoint such as: antrochoanal polyps, nasal septal deviation that would occlude at least 1 nostril, acute sinusitis, nasal infection or upper respiratory infection at screening or within 2 weeks before screening, ongoing rhinitis medicamentosa; known or suspected diagnosis of cystic fibrosis; chronic granulomatous disease and granulomatous vasculitis, granulomatosis with polyangiitis (Wegener's Granulomatosis), eosinophilic granulomatous with polyangiitis (Churg-Strauss syndrome), Young's syndrome, primary dyskinetic ciliary syndromes (eg, Kartagener's syndrome) or other dyskinetic ciliary syndromes
Signs or a CT scan suggestive of Allergic Fungal Rhinosinusitis
Patients with co-morbid asthma are excluded if
Forced Expiratory Volume in 1 second (FEV1) 50% of normal predicted value OR
An exacerbation within 90 days prior screening that required hospitalization (> 24 hours) OR
Are on a daily dose of inhaled corticosteroids (ICS) higher than 1000 mcg fluticasone or the equivalent
Known or suspected history of immunosuppression, including history of invasive opportunistic infections, such as aspergillosis, coccidioidomycosis, histoplasmosis, human immunodeficiency virus (HIV), listeriosis, pneumocystosis, or tuberculosis, despite infection resolution; or unusually frequent, recurrent or prolonged infections. Tuberculosis testing would be performed on a country-by-country basis according to local guidelines if required by regulatory authorities or ethics committees
Patients who have active Hepatitis B, Hepatitis C or HIV infections as determined by positive results at Screening for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb); or hepatitis C (HCV) antibody; or positive HIV serology. Note: Patients who test positive for HBvAb, negative for HBsAg and subsequently confirmed positive for HBsAb, indicating resolved natural infection (confirmed by negative HBV-DNA), may participate. Patients with positive HCV may participate if subsequent viral load is confirmed negative
A helminth parasitic infection diagnosed within 24 weeks prior to the date of informed consent that has not been treated, or has failed to respond to, standard of care therapy
Evidence of infection requiring treatment with systemic antibacterials, antivirals, antifungals, antiparasitics, or antiprotozoals within 7 days before baseline, or viral infections within 14 days before screening that may not have received antiviral treatment
Live, attenuated vaccinations within 28 days prior to screening or planned live, attenuated vaccinations during the study
Pregnant or intent to become pregnant during the study, or breast-feeding women
Any disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric, or major physical impairment that is not stable in the opinion of the investigator and may affect the safety of the patient throughout the study, or influence the findings of the studies or their interpretations, or impede the patient's ability to complete the entire duration of study
Any clinically significant abnormal findings in physical examination, vital signs, safety lab tests during screening/run-in period, which in the opinion of the investigator, may put the patient at risk because of their participation in the study, or may influence the results of the study, or the patient's ability to complete entire duration of the study
Have any of the following laboratory abnormalities at Screening
Eosinophils >1500 cells/mm3 (or 1.5 x 10E9/L)
Platelets <100000 cells/mm3 (or 100 x 10E9/L)
Creatine phosphokinase (CPK) > 10 upper limit of normal (ULN)
Alanine aminotransferase (ALT) > 2.5 times the ULN
Aspartate aminotransferase (AST) 2.5 times the ULN
Bilirubin 2 times the ULN
History of alcohol or drug abuse within 12 months prior to the date informed consent
An allergy to L-histidine, trehalose or Tween (polysorbate) 80 or a history of a systemic hypersensitivity reaction, other than localized injection site reaction, to any biologic drug
Plans to undergo any surgical procedure requiring general anesthesia during the study
History of cancer: Patients who have had basal cell carcinoma, localized squamous cell carcinoma of the skin, or in situ carcinoma of the cervix are eligible provided that the patient is in remission and curative therapy was completed at least 12 months prior to the date informed consent. Note: Patients who have had other malignancies are eligible provided that the patient is in remission and curative therapy was completed at least 5 years prior to the date of informed consent
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