Effect of Latanoprostene Bunod Ophthalmic Solution 0.024% on Episcleral Venous Pressure and Outflow Facility in Ocular Hypertensive Subjects

  • participants needed
  • sponsor
    Bausch & Lomb Incorporated
Updated on 22 September 2023
screening examination
corrected visual acuity
ophthalmic solution
brimonidine tartrate ophthalmic solution
intraocular pressure
aqueous humor
ocular hypotensive
optic neuropathy


The primary objective of this study is to determine the effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% (a single dose and 7 days of once daily [QD] dosing) on 2 aspects of aqueous humor (AqH) dynamics (episcleral venous pressure [EVP] and outflow facility) in participants with ocular hypertension (OHT).


All participants will receive both the investigational (LBN ophthalmic solution 0.024%) and placebo treatments, with 1 eye receiving LBN 0.024% and the contralateral eye receiving placebo. Each participant will be randomized as to which eye (right or left) will receive LBN 0.024% versus placebo.

All participants will undergo a minimum 14-day to maximum 42-day washout period prior to the start of study drug administration.

Condition Ocular Hypertension
Treatment Placebo, Latanoprostene Bunod, Latanoprostene Bunod
Clinical Study IdentifierNCT04140279
SponsorBausch & Lomb Incorporated
Last Modified on22 September 2023

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