The primary objective of this study is to determine the effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% (a single dose and 7 days of once daily [QD] dosing) on 2 aspects of aqueous humor (AqH) dynamics (episcleral venous pressure [EVP] and outflow facility) in participants with ocular hypertension (OHT).
All participants will receive both the investigational (LBN ophthalmic solution 0.024%) and placebo treatments, with 1 eye receiving LBN 0.024% and the contralateral eye receiving placebo. Each participant will be randomized as to which eye (right or left) will receive LBN 0.024% versus placebo.
All participants will undergo a minimum 14-day to maximum 42-day washout period prior to the start of study drug administration.
| Condition | Ocular Hypertension |
|---|---|
| Treatment | Placebo, Latanoprostene Bunod, Latanoprostene Bunod |
| Clinical Study Identifier | NCT04140279 |
| Sponsor | Bausch & Lomb Incorporated |
| Last Modified on | 22 September 2023 |
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