Comparison of Hemostatic Agent to Suture in Terms of Hemostatic Function and Preservation of Ovarian Function

  • End date
    Dec 31, 2026
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 3 July 2021


This study aims to evaluate the efficacy of preservation of ovarian function, hemostasis, and safety of a hemostatic agent versus suturing during laparoscopic ovarian cystectomy for ovarian endometriosis.


In women with endometrioma who plan to undergo laparoscopic ovarian cystectomy, surgical technique can influence postoperative ovarian function because of removal of normal ovarian tissue with ovarian cyst and damage to ovarian tissue during bleeding control after stripping of endometrioma. This study is designed to compare hemostatic sealant to suturing in terms of hemostatic function, safety and preservation of ovarian function.

Ovarian function of all patients will be evaluated on pre op, post op 12 weeks, post op 48 weeks by measuring AMH and ovarian volume. And Hemostatic function will be evaluated by measuring serum hemoglobin, blood loss during operation, etc.

Condition Benign Ovarian Cyst
Treatment Hemostatic agent (EVICEL®) application during laparoscopic ovarian cystectomy, suturing with barbed sutures during laparoscopic ovarian cystectomy
Clinical Study IdentifierNCT04643106
SponsorSeoul National University Hospital
Last Modified on3 July 2021


Yes No Not Sure

Inclusion Criteria

Informed consent
Age: 19-45 year-old women
American Society of Anesthesiologists Physical Status classification 1 or 2
Plan of laparoscopic ovarian cystectomy for unilateral or bilateral ovarian endometriosis diagnosed by ultrasonography
Regular menstruation every 21-45 days

Exclusion Criteria

No 'ovarian' endometriosis
Suspicious disease of ovarian malignancy
Age: 18 and younger, 46 and older
Pregnancy or breastfeeding
Lower than 0.05 ng/ml of serum Anti-mullerian hormone level
Hormonal therapy within recent 3 months
Considered as inappropriate by the researcher's judgment
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