Evaluation of Dopaminergic Denervation by DaTSCAN Brain Scintigraphy Using a New Multipurpose CZT System (STARDAT)

  • STATUS
    Recruiting
  • days left to enroll
    90
  • participants needed
    55
  • sponsor
    Centre Hospitalier Régional d'Orléans
Updated on 25 January 2022
SPECT Scan
datscan

Summary

DaTSCAN is an important tool in the diagnosis and clinical management of Parkinson's syndromes.

New cadmium-zinc-telluride (CZT) systems allow time and/or dose reduction. This can be interesting in DaTSCAN acquisitions as those are long-lasting, often on difficult patients.

This study will evaluate the diagnostic performances of a new 3D-ring CZT camera in DaTSCAN SPECT.

Description

DaTSCAN is an important tool in the diagnosis and clinical management of Parkinson's syndromes, particularly for the diagnosis of Parkinson's disease or in the exploration of dementia-type neurodegenerative diseases.

The acquisition of tomoscintigraphic images is performed 3 hours after injection and lasts approximately 30 minutes on a conventional gamma camera.

Recently, the introduction of systems equipped with cadmium-zinc-telluride (CZT) technology has made it possible to reduce acquisition times and/or injected doses. Among these systems, some new 3D-ring CZT cameras allow tomoscintigraphic acquisitions to be carried out from the outset for the exploration of different organs.

Patients included in this study will be double scanned both on a conventional camera and on the new multipurpose CZT system, with CT.

The primary objective is to evaluate the diagnostic concordance between the DaTSCAN brain scintigraphy images from the new CZT SPECT/CT system and those from the conventional SPECT camera, when visually interpreted blindly by experienced observers (nuclear medicine physicians), according to a diagnostic scale.

Striatal binding ratios (SBR) will also be compared. Time reduction will also be evaluated on DaTSCAN SPECT data from the new multi-purpose CZT system.

Details
Condition Parkinson Disease
Treatment Additional acquisition
Clinical Study IdentifierNCT04934046
SponsorCentre Hospitalier Régional d'Orléans
Last Modified on25 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients referred to our Nuclear Medicine department for DaTSCAN scintigraphy

Exclusion Criteria

Under 18 years-old patients
Pregnant women or at risk of pregnancy
Breast feeding
Painful patients
Patients under guardianship
Patients in whom a standard examination is not feasible (agitation)
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