Early Detection of Myocardial Work Impairment in Obesity II(EARLY-MYO-OBESITY-II)

  • STATUS
    Recruiting
  • days left to enroll
    33
  • participants needed
    200
  • sponsor
    RenJi Hospital
Updated on 8 July 2022
Accepts healthy volunteers

Summary

This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.

Description

Obesity significantly increases the risk for heart failure. Early detection of preclinical cardiac dysfunction in overweight or obesity and understanding its association with insulin resistance are of great importance.Recently, a novel technique for myocardial work (MW) assessment has been introduced to evaluate myocardial performance. To date, change of MW has been described in several cardiac conditions including dilated cardiomyopathy, significant coronary arterial diseases, and hypertrophic cardiomyopathy, which implies regional or global myocardial dysfunction. In this study, we aimed to explore the alteration of MW in overweight or obese adults and to determine whether insulin resistance or other clinical risk factors may impact myocardial mechanics before impairment of systolic function.

Details
Condition Overweight and Obesity
Treatment Myocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
Clinical Study IdentifierNCT04933188
SponsorRenJi Hospital
Last Modified on8 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

All patients were older than 18 without any cardiac symptoms
The diagnosis of overweight was established when body mass index (BMI) of 25 to 30 kg/m2
Obese was defined as a BMI of 30 kg/m2 or higher

Exclusion Criteria

diagnosis of type 2-Diabetes Mellitus according to the American Diabetes Association criteria
left ventricular ejection fraction<50% on echocardiography
arrythmia on electrocardiogram
severe valvular stenosis or regurgitation
history of coronary disease (defined as stenosis>50%) or myocardial infarction
stress induced wall motion abnormality on echocardiography, coronary artery stenosis >50% on coronary CT or angiography with Framingham risk score of >10
pacemaker or defibrillator implantation
the presence of bundle branch block
severe infection or renal dysfunction with an estimated glomerular filtration rate < 60 ml/min/1.73 m2)
inadequate image quality on echocardiography
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