Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects

  • End date
    Dec 28, 2022
  • participants needed
  • sponsor
    SVS Institute of Dental Sciences
Updated on 28 June 2021


The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues. Many surgical techniques have been used to regenerate intrabony defects (IBD).

Titanium stimulates activation of the complement system, surface binding of platelets, and platelet activation as reflected by increased levels of platelet-derived growth factor, which is a substantial promoter of bone growth. Hence we may speculate that using a bone substitute made of titanium may be positive from the perspective of bone formation in osseous defects.


Titanium granules consist of irregular porous granules of commercially pure titanium. The porous properties may lead to ingrowth of newly formed bone.The osseointegrating response to titanium may be the result of the potent activation of the intrinsic coagulation system and the subsequent release of growth factors from platelets.Therefore, the aim of this study is to compare the effect of titanium particles and hydroxyapatite on osseous regeneration in intrabony defects.

After reflection of flap and degranulation, bone graft i.e., titanium particles (test group) or hydroxyapatite(control group) will be placed in the void created by the defect and sutures will be placed.

Condition Intrabony Periodontal Defect
Treatment Titanium Granules, Hydroxyapatite, Hydroxyapatite
Clinical Study IdentifierNCT04932161
SponsorSVS Institute of Dental Sciences
Last Modified on28 June 2021


Yes No Not Sure

Inclusion Criteria

Systemically healthy male and female patients of age >18 years with two-walled
or three-walled intrabony defects and probing pocket depths (PPD) of >3mm

Exclusion Criteria

Medically compromised patients, patients <18 years of age, pregnant women
heavy smokers, and patients who underwent radiotherapy or chemotherapy are
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