Prevention and Early Detection of Cervical Cancer Through Self-Administered Screening

  • days left to enroll
  • participants needed
  • sponsor
    University of California, San Francisco
Updated on 12 May 2022
hpv vaccine
diagnostic procedures
cervical disease
human papilloma virus vaccine
hpv test
prevention of cervical cancer
cancer prevention
Accepts healthy volunteers


This study examines prevention and early detection of cervical cancer through self-administration screening of patients in Western Uganda. The cervix is the opening of the uterus or womb, which is the organ that supports babies before they are born. There are simple tests that let doctors know whether or not patients have cells that may become cancer. Some of the tests determine whether patients have an increased risk for cervical disease, but they do not actually confirm that they have it: these are called "screening" tests. This study may help researchers determine how to best deliver cervical cancer prevention services using the HPV test.



I. To establish the acceptance and correlates of self-collected human papillomavirus (HPV)-ribonucleic acid (RNA) testing among women in the rural Ugandan community as well as the incidence and determinants of successful completion of the cervical cancer screening cascade from self-collected HPV testing to receipt of results.

II. To ascertain the frequency and determinants of successful acquisition of treatment among women who have HPV detected on self-collected swabs in rural Uganda.

III. To derive population-based estimates of the prevalence of high-risk HPV and cervical intraepithelial neoplasia (CIN) detected through community-based screening employing self-collected HPV RNA testing in rural Uganda.


Patients receive a specimen kit for collection of HPV samples. Patients complete questionnaire before and after collection HPV samples. Patients may also participate in an interview about general ideas in improving the screening and treatment process. Patients with positive results, undergo treatment for cervical cancer.

Condition Cervical Carcinoma, Human Papillomavirus-Related Carcinoma
Treatment questionnaire administration, HPV testing
Clinical Study IdentifierNCT04927650
SponsorUniversity of California, San Francisco
Last Modified on12 May 2022


Yes No Not Sure

Inclusion Criteria

Women in the three Ugandan districts (Kiboga, Kyankwanzi and Hoima) who access screening during the community health campaigns
Age 25-49 years
Resident in the study district
Provision of informed consent

Exclusion Criteria

Clinical signs and symptoms of cancer of the cervix
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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