Remote Ischemic Conditioning in Oncology (RICO)

  • End date
    Sep 8, 2023
  • participants needed
  • sponsor
    Children's Hospital Medical Center, Cincinnati
Updated on 11 July 2022


This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients undergoing anthracycline chemotherapy for Hodgkin disease and soft-tissue and bone sarcoma who meet eligibility requirements will be approached to participate in the study. The purpose of the study is to determine if performing remote ischemic conditioning (RIC) is feasible in children and young adults receiving anthracycline chemotherapy. The secondary purpose is to describe differences in markers of myocardial injury and stress in children and young adults that receive RIC prior to anthracycline chemotherapy compared to control subjects that receive sham therapy prior to chemotherapy.

Condition Participants Undergoing Anthracycline Chemotherapy
Treatment autoRIC®
Clinical Study IdentifierNCT04805346
SponsorChildren's Hospital Medical Center, Cincinnati
Last Modified on11 July 2022


Yes No Not Sure

Inclusion Criteria

Pediatric, adolescent, or young adult patients, 11 years of age or above
Able to tolerate upper arm blood pressure inflation

Exclusion Criteria

Previous diagnosis of cardiomyopathy (dilated, hypertrophic, restrictive, myocarditis) or congenital heart disease other than bicuspid aortic valve
Chronic kidney disease as defined as a pre-transplant GFR <80
Central line in both upper extremities
Known peripheral vascular disease or vasculitis
Platelet count less than 30,000
Known clotting disorder or hypercoagulability
Non-English-speaking patients
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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