Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections

  • STATUS
    Recruiting
  • days left to enroll
    66
  • participants needed
    15
  • sponsor
    Wake Forest University Health Sciences
Updated on 14 May 2022
antibiotics
bacteremia
carbapenem
ceftazidime
imipenem
cilastatin

Summary

This is an observation study comparing prospective use of Imipenem/Cilastatin/Relebactam (IMI/REL) to retrospective data using Meropenem/Vabobactam (MVB)and Ceftazidime/Avibactam CZA) in treatment of Klebsiella Producing Carbapenemase Enterobacteriaceae infections at a tertiary care hospital. The objectives of the study are to demonstrate successful treatment of KPC containing Enterobacteriaceae infections with IMI/REL including in bacteremia, and to analyze treatment outcomes in use of IMI/REL for KPC-producing infections compared to historical clinical outcome data with CZA and MVB use at the same institution.

Details
Condition Carbapenem-Resistant Enterobacteriaceae Infection, KPC, Gram-Negative Bacterial Infections, Antibiotic Resistant Infection
Treatment Imipenem+Relebactam
Clinical Study IdentifierNCT04785924
SponsorWake Forest University Health Sciences
Last Modified on14 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult (>18 years of age) patients with a KPC-producing CRE infection at any site except for isolated urinary source. Patients may be initially enrolled once identified with a CRE infection defined as resistance to any carbapenem. Any carbapenem resistance will provide an initial mechanism of identifying study eligible patients in accordance with our institutions definition of CRE for infection prevention purposes. As this study is specific for KPC-producing CRE inclusion in the study analysis will require confirmation of a KPC gene by molecular analysis of the isolate and subjects enrolled may be subsequently removed from study and excluded from analysis if molecular testing reveals their CRE isolate to be a non-KPC mechanism of resistance. Polymicrobial infections at same or different sites can also be included as long as additional gram-negative active agents aside from IMI/REL are not needed for treatment
Bacterial infection with Enterobacteriaceae excluding Morganellaceae
Ability and willingness to give informed consent. A Legal authorized representative may be used when the patient is unable to provide informed consent
Be the first episode of a CRE infection to be treated with IMI/REL. Previously treatment with IMI/REL for a KPC-containing Enterobacteriaceae infection will exclude patients from enrollment

Exclusion Criteria

Receipt of more than 48 hours of effective antibiotic therapy against KPC containing infections (e.g. MVB, CZA) prior to first dose of IMI/REL being administered
Infections localized to urinary source alone (bloodstream infections from urinary source will be included)
Infection with Morganellaceae
Prior serious allergic reaction to carbapenem therapy
Need for ongoing concomitant therapy with ganciclovir or valproic acid
Need for ongoing concomitant therapy with another antibiotic active against gram negative pathogens. Concomitant therapy with Vancomycin, Daptomycin, Linezolid, Clindamycin, Fidaxomicin, Nafcillin, Metronidazole, and Rifaximin will be allowed but no other antibiotic agents
Pregnancy or ongoing breastfeeding. Women of childbearing age must test negative on a urine pregnancy test at time of screening for trial eligibility and remain either abstinent or use 2 forms of highly effective contraception for the duration of the IMI/REL administration during the study
Inability to comply with study protocol or remain hospitalized for duration of study
Life expectancy less than 72 hours in opinion of study investigators
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