Prospective Trial of Induction Immunotherapy in Locally Advanced or Oligometastatic NSCLC Without a Primary Curative Option

  • STATUS
    Recruiting
  • End date
    Dec 31, 2025
  • participants needed
    50
  • sponsor
    Klinikum Esslingen
Updated on 4 October 2022
chemoradiotherapy
cancer chemotherapy

Summary

In a certified lung- cancer center, patients with NSCLC and a potentially curative stage (including patients with oligometastatic disease) are prospectively enrolled if curative treatment (either definitive radio-chemotherapy or resection) cannot be performed due to large tumor size or for functional reasons. For these patients, the multidisciplinary tumor board (MDB) recommends immuno-(chemo)therapy and re-evaluation. Response is assessed radiologically including PET-CT if indicated. After review of the MDB, patients receive either definitive curative treatment or palliative treatment.

Description

In a certified lung- cancer center, patients with NSCLC and a potentially curative stage (including patients with oligometastatic disease) are prospectively enrolled if curative treatment (either definitive radio-chemotherapy or resection) cannot be performed due to large tumor size or for functional reasons (e. g. too large radiation field or functionally inoperable for the required resection). For these patients, the multidisciplinary tumor board (MDB) recommends immuno-(chemo)therapy and re-evaluation. Response is assessed radiologically including PET-CT if indicated. After review of the MDB, patients receive either definitive curative treatment or palliative treatment.

Details
Condition Non-Small Cell Lung Cancer
Treatment Induction therapy
Clinical Study IdentifierNCT04926584
SponsorKlinikum Esslingen
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

newly diagnosed NSCLC
histologically or cytologically proven
stage III - IVA (oligometastatic) by complete staging
ECOG 0-2
life expectancy 3 months
ability to provide written informed consent

Exclusion Criteria

primary resectability
primary definitive chemoradiotherapy feasible
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