Efficacy of Nafamostat in Covid-19 Patients (RACONA Study)

  • STATUS
    Recruiting
  • days left to enroll
    88
  • participants needed
    256
  • sponsor
    University Hospital Padova
Updated on 19 June 2021

Summary

RACONA is a prospective trial that will test the hypothesis that nafamostat can lower lung function deterioration and need for intensive care admission in COVID-19 patients.

Design: Adult hospitalized COVID-19 patients will be randomized in a prospective double-blind randomized placebo-controlled study to test the clinical efficacy of nafamostat mesylate (administered intravenously) on top of best standard of care.

Primary outcome measures: the time-to-clinical improvement, defined as the time from randomization to an improvement of two points (from the status at randomization) on a seven category ordinal scale or live discharge from the hospital, whichever comes first.

Description

Purpose: SARS-Cov-2 enters the lung cells by binding to ACE-2 and activating the protease TMPRSS2, which, therefore, can be a target for antiviral treatment. Accordingly, TMPRSS2 inhibitors prevent SARS-CoV cell entry in vitro. The most potent such inhibitors, nafamostat is being used as anticoagulant and anti-pancreatitis agent, and is approved for the treatment of cystic fibrosis as its mucolytic action can prevent lung function deterioration by owering airways infections.

RACONA study will test the hypothesize that nafamostat is useful in COVID-19 lung involvement because COVID-19 entails activation of the coagulation cascade, pulmonary embolism, and bacterial superinfections.

Details
Condition COVID19
Treatment Placebo, Nafamostat Mesilate
Clinical Study IdentifierNCT04352400
SponsorUniversity Hospital Padova
Last Modified on19 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Hospitalized, COVID-19 positive, between 18 and 85 years of age
Signed Inform Consent Form
Body temperature > 37.3
Oxygenation criterion (any of the following): i) Oxygen saturation 94% on Room Air; ii) PaO2/FiO2 ratio 300 mmHg but > 100 mmHg, if patient on supplemental oxygen; iii) SpO2/FiO2<200 if no arterial blood gas available
Respiratory rate (RR) 25 beats/min

Exclusion Criteria

Pregnant or lactating females
Unwillingness or inability to complete the study
Rapidly deteriorating clinical condition or low likelihood to complete the study according to the investigator
eGFR < 30 ml/min/m2 assessed with CKD EPI formula
Current or chronic history of liver disease (Child Pugh score 10), or known hepatic or biliary abnormalities
Participation in a clinical trial with an investigational product within the following time period prior to the first dosing day in the current study: 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer)
Patients requiring high doses of loop diuretics (i.e. > 240 mg furosemide daily) with significant intravascular volume depletion, as assessed clinically
History of allergy
History of sensitivity to heparin or heparin-induced thrombocytopenia
Unstable hemodynamics in the preceding 4 hours (SBP < 90 mmHg, and/or vasoactive agents required)
Hemoglobin < 7 at time of drug infusion. Transfusion is allowed to increase hemoglobin levels before entry into the study
Malignancy or any other condition for which estimated 6-month mortality >50%
Arterial blood pH less than 7.2
Known evidence of chronic interstitial infiltration at imaging
Known hospitalization within the past six months for respiratory failure (PaCO2 > 50 mmHg or PaO2 < 55 mmHg, or oxygen saturation <88% on FiO2 = 0.21)
Known chronic vascular disease resulting in severe exercise restriction (i.e. unable to perform household duties)
Known secondary polycythemia, severe pulmonary hypertension, or ventilator dependency
Known vasculitis with diffuse alveolar hemorrhage
Pre-existing renal failure on hemodialysis or peritoneal dialysis requiring renal replacement therapy
Extracorporeal membrane oxygenation (ECMO)
Immunosuppressive treatment
Patient in trials for COVID-19 within 30 days before
Unstable hemodynamics in the preceding 4 hours (MAP 65 mmHg, or SAP < 90 mmHg, DAP < 60 mmHg, and vasoactive agents required)
Hyperkalemia , i.e. serum K+ levels > 5.0 mEq/L
Severe active bleeding
Any other uncontrolled comorbidities that increase the risks associated with the study drug administration, as assessed by the medical expert team
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