MicroRNA Correlates of Childhood Maltreatment and Suicidality

  • STATUS
    Recruiting
  • End date
    Sep 9, 2025
  • participants needed
    450
  • sponsor
    University of Alabama at Birmingham
Updated on 9 July 2021
depression
depressed mood

Summary

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into protein) that are found in throughout the body and blood. They are called microRNA because their size is much smaller than typical RNA molecules. miRNAs are highly responsive to environment. This responsiveness is reflected in their expression in individuals who are affected by environment such as stress. The investigators are gathering genetic material, including DNA and RNA, from each participant. The RNA will be taken from the small vesicles and cells in the participant's blood and analyzed. The vesicles are small objects that occur normally in the blood and that contain RNA. This information may help us to understand the cause of mental illness and to improve medical and psychiatric care in the future. There will be 450 participants enrolled in this study.

Description

The purpose of the study is to determine if the relationship between a history of childhood maltreatment (CM) and suicide risk is associated with alterations in the expression and epigenetic modification of specific microRNAs (miRNAs), thereby providing a molecular signature of suicide risk in people with CM. miRNAs are short regulatory RNAs that transduce environmental events into changes in protein synthesis in cells. The environment can induce permanent changes in miRNA expression. Aim 1 is to identify a set of neural-derived exosomal miRNAs that are associated with the interaction of suicidality and CM. Aim 2 is to examine whether an acute experimental stressor, the Trier Social Stress Test (TSST), impacts the expression of these miRNAs in suicidal patients with and without CM. Aim 3 will examine potential mechanisms by which altered miRNAs may contribute to CM-associated suicidal behavior. Aim 4 will examine if changes in CM-associated miRNAs are explained by modifications in their DNA methylation.

Details
Condition Major depression, Endogenous depression, Suicidal Ideation, major depressive disorders, Suicide, major depressive disorder
Treatment Trier Social Stress Test
Clinical Study IdentifierNCT04923685
SponsorUniversity of Alabama at Birmingham
Last Modified on9 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18-60
Physically healthy
Willing and able to provide informed consent
Diagnosis of MDD or No history of mental illness

Exclusion Criteria

Pregnancy or lactation (women of reproductive potential must have a negative urine pregnancy screen)
Post-partum state (being within 2 months of delivery or miscarriage)
Homicide risk as determined by clinical interview
A lifetime history of psychotic disorder
Any history of dissociation or dissociative disorder
Bipolar disorder
Pervasive developmental disorder
Cognitive disorder
Cluster A personality disorder
Borderline personality disorder
Anorexia nervosa
Alcohol or drug dependence (except nicotine and caffeine) within the last month or the use of any hallucinogen (except cannabis), including phencyclidine in the last month (NOTE that a positive UDS is not exclusionary except for hallucinogens, methamphetamine, or cocaine. People presenting intoxicated with alcohol may be included when a Breathalyzer test (Alco-Sensor IV) is negative as long as there is no history of recent dependence
Recent myocardial infarction
Unstable angina
Active neoplasm in the past 6 months
Immunosuppressive or corticosteroid therapy within the last month, with the following exceptions: any inhaled, intranasal, topical or vaginal corticosteroids are allowed
Chemotherapy
Head injury with loss of consciousness in the past 6 months
Clear my responses

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