The Research of Human Cortex Cell Atlas

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 21 June 2021


In this study, the single-cell transcriptome sequencing technology was used to study the transcriptome differences at the single-cell level in normal human brain, aging human brain, and epileptic brain.


The human brain has about 100 billion cells and makes up neural networks.The abnormal activity of neurons can affect the operation of neural networks, leading to neurological diseases.With the coming of the age of global population aging, neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's have become an increasing burden on human health.

Cells are the basic unit of brain. Understanding the mechanism of brain activities includes not only the mechanism of neural network, but also the self-regulation of its basic unit, that is, the regulation of gene expression based on brain activity.The abnormal expression and regulation of genes lead to the abnormal activities of the nervous system.Therefore, studying the regulation mechanism of gene expression at the cellular level is an important way to research brain diseases.The recent development of single-cell RNA-sequencing technology provides a possibility to understand the functioning mechanism of the brain at the cellular level.

Condition Aging, Epilepsy, Senility, epilepsia, Brain Injury, epileptics, seizure disorder, Seizure Disorders (Pediatric), epileptic, Seizure Disorders
Treatment brain tissue single-cell sequencing
Clinical Study IdentifierNCT04926987
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on21 June 2021


Yes No Not Sure

Inclusion Criteria

Craniocerebral injury patients needing operative treatment
Treatment-resistant epilepsy patients needing resection surgery

Exclusion Criteria

Vital signs unstable
Incomplete medical history, imaging and clinical diagnosis
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