Detecting HPV DNA in Anal and Cervical Cancers

  • STATUS
    Recruiting
  • End date
    Nov 15, 2023
  • participants needed
    20
  • sponsor
    University of Chicago
Updated on 23 June 2021
x-rays
human papillomavirus
diagnostic procedures
human papilloma virus vaccine
human papillomavirus dna

Summary

This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, and after radiation treatment. They will also collect blood and archival tumor tissue (from a previous biopsy) to perform other tests in the future that could provide more information about HPV-associated cancers and how they respond to treatment. Participation in this study will last approximately 2 years.

Details
Condition Uterine Serous Carcinoma, Anal Cancer, cervical cancer, uterine, Uterine Cancer, cervical carcinoma, HPV-Related Cervical Carcinoma, anal carcinoma, carcinoma of the cervix uteri, carcinoma of cervix, cancer of the cervix, Rectal Cancer, Cervical Cancer, carcinoma of the cervix, HPV-Related Carcinoma, HPV-Related Anal Squamous Cell Carcinoma, cervix cancer, Disorders of cervix NOS
Treatment Blood sample collection, Physical Exam, Radiation Treatment With or Without Chemotherapy, HPV Genotyping (HPV DNA Test), Testing Archival Tumor Tissue, Positron Emission Tomography Scan (PET Scan)/ Computed Tomography Scan (CT Scan)
Clinical Study IdentifierNCT04857528
SponsorUniversity of Chicago
Last Modified on23 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Stage I-III anal cancer or stage I-IVA cervical cancer that is p16+ based on immunohistochemistry
Age 18 years
Planned to undergo radiation therapy as definitive treatment, with or without concurrent systemic therapy

Exclusion Criteria

Anal carcinoma not associated with HPV-16, 18, 31, 33, or 35 will be removed from the
Planned to undergo radiation therapy as an adjuvant or post-operative therapy
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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