Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance

  • STATUS
    Recruiting
  • participants needed
    60
  • sponsor
    St. Justine's Hospital
Updated on 28 September 2022

Summary

The main objective is to study the effect of polyphenol supplementation on hepatic steatosis as measured by hepatic ultrasound, hepatic elastography and magnetic resonance hepatic spectroscopy in obese adolescents known for hepatic steatosis as diagnosed by liver biopsy

Description

Obesity leads to hepatic steatosis. Early changes in vascular compliance due to obesity have been shown to be reversible. Many studies have shown a positive effect of polyphenols (natural product in apples and grapes) on the liver fat burden. Three visits will be planified.

Visit 1: Demographic data and liver and vascular imaging. Blood and stool tests.

Randomization to polyphenol versus placebo. Visit 2 at 60 days. Demographic data and liver and vascular imaging. Blood tests. Stop the intervention.

Visit 3 at 120 days. Demographic data and liver and vascular imaging. Blood and stool tests.

This study will determine the feasibility of a randomized controlled trial evaluating the effect of polyphenols on hepatic steatosis and the vascular subclinical radiologic changes related to obesity.

Details
Condition Intimal Hyperplasia, steatohepatitis, hepatic steatosis, Obesity, Childhood, Intimal Proliferation, Fatty Liver
Treatment Effect of polyphenols on hepatic steatosis and vascular elastography and intima media thickness
Clinical Study IdentifierNCT03994029
SponsorSt. Justine's Hospital
Last Modified on28 September 2022

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