Study of Efficacy Safety and Tolerability of LNA043 in Patients With Knee Osteoarthritis

  • End date
    Jun 14, 2027
  • participants needed
  • sponsor
    Novartis Pharmaceuticals
Updated on 26 August 2021
body mass index


The study will determine the optimal dosing regimen of LNA043 in patients with knee osteoarthritis (OA).

Condition Arthritis, Osteoarthritis, degenerative arthritis
Treatment Placebo, LNA043 Dosing Regimen A, LNA043 Dosing Regimen B, LNA043 Dosing Regimen C, LNA043 Dosing Regimen D
Clinical Study IdentifierNCT04864392
SponsorNovartis Pharmaceuticals
Last Modified on26 August 2021


Yes No Not Sure

Inclusion Criteria

Males and females between 40 and 75 years of age
Body mass index (BMI) < 40 kg/m2
Diagnosis of primary tibiofemoral knee OA by standard American College of Rheumatology clinical and radiographic criteria
and other criteria as specified by the protocol

Exclusion Criteria

Participants with radiographic knee OA K-L grade = 4 on the non-target knee
Arthroscopy of the target knee within the 6 months prior to Screening
Hemoglobin < 8.5 g/dL (85 g/L) or platelet count < 100,000/L
and other criteria as specified by the protocol
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