Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor

  • STATUS
    Recruiting
  • End date
    Mar 12, 2022
  • participants needed
    10
  • sponsor
    University of California, San Diego
Updated on 12 June 2021

Summary

This trial will be done in participants who undergo transplantation of heart, kidney or lung at University of California, San Diego (UCSD) and receive a hepatitis C infected donor organ. In this trial, the plan is to start hepatitis C treatment just before transplant surgery and treat for a short one-week course to see if hepatitis C infection can be prevented in the transplant recipient. The plan is to perform this trial in 10 participants and if successful, the next step is to try to make it standard of care as prevention of infection is better than treating hepatitis C after discharge from transplant surgery (which is usually a 12 week standard treatment).

Details
Condition Hepatitis C, Hepatitis C virus, Hepatitis C Virus Infection, Response to Therapy of, Hepatitis C Virus Infection, Response to Therapy of
Treatment glecaprevir/pibrentasvir (GLE/PIB)
Clinical Study IdentifierNCT04596475
SponsorUniversity of California, San Diego
Last Modified on12 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

adults aged 18 years or greater
participants actively listed for heart, lung and/or kidney transplant
participants have already consented to receive HCV-viremic organs as part of the institution's clinical practice protocol (involves education and informed consent), and are able to sign informed consent for this research study

Exclusion Criteria

participants who have a prior history of HCV infection regardless of treatment status, pre-existing human immunodeficiency virus (HIV) or hepatitis B virus (HBV) infection
participants who are not able to sign informed consent for this research study
participants who have not agreed to accept HCV+ organs as part of the UCSD clinical practice protocol
participants who are listed for a liver transplant (either as a single organ or combined organ transplant)
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note