Evaluation of a Phyto Aromatherapy Treatment in the Management of Recurrent Cystitis

  • STATUS
    Recruiting
  • End date
    Nov 1, 2023
  • participants needed
    15
  • sponsor
    Centre Hospitalier Universitaire de Nice
Updated on 14 June 2021

Summary

Half of the women have a once-in-a-lifetime episode of cystitis. Recurrence occurs in about 20% to 30% of patients, and half of these patients will have more than 4 episodes per year, defining recurrent cystitis.

The clinical assessment sometimes brings to light favourable factors; variables in pre- or post-menopause; but in the majority of cases, no explanatory cause can solve the problem and some authors refer to resignation as a classic reaction to this problem.

several countries have already opted for alternative treatments (Nonsteroidal anti-inflammatory drugs, phytotherapy, diuresis treatment), especially since the pressure of antibiotic selection is at the root of the dramatic spread of bacterial resistances.

There is a growing interest in the potential of complementary medicine to assist in this care. Products based on cranberries, for example, have been particularly studied and a 2012 Cochrane review concluded that there is a benefit with an estimated risk reduction of between 10 and 20%. Another "alternative" approach is the use of Chinese medicinal herbs. These herbs have been used for more than 2000 years.

The implementation of phyto-aromatherapy treatment implies a global management of patients with recurrent cystitis. Initially, it involves a curative phase as soon as the first symptoms of the attack appear, thanks to a mixture of antibacterial essential oils. In a second phase, it integrates a preventive phase over several months thanks to an association of medicinal plants whose effects in this field have been proven in vitro and in vivo, allowing to rebalance a "terrain" associating anxiety, hypersensitivity to pain, a terrain willingly associated with the irritable bowel syndrome in these patients. While having few side effects, the plants will act, in the long term, at different levels: directly on the cause of the disease thanks to their antiseptic, antiadhesive and diuretic activities, but also by reducing the symptoms thanks to their anti-inflammatory, analgesic, antispasmodic and anxiolytic activities.

Investigators hypothesize that patients with recurrent cystitis can be improved by a two-phase, multi-plant, phyto-aromatherapy treatment combining several plants: the treatment of attacks, by aromatherapy, and a prophylactic treatment, by phytotherapy. In the absence of any such studies published in the literature, investigators propose a non-randomised prospective monocentric interventional pilot study on 15 patients with proof of concept and feasibility.

Details
Condition Cystitis Recurrent
Treatment CYSCONTROL/PHYTOCYST Herbal tea
Clinical Study IdentifierNCT04747041
SponsorCentre Hospitalier Universitaire de Nice
Last Modified on14 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women aged 18 or older
Affiliated to social security
Presenting recurrent cystitis defined by a frequency of at least 4 episodes per year
For women of childbearing age: effective contraception followed for at least 3 months prior to the start of the study and agreeing to keep it throughout the study period
Available to consult a phyto-aromatherapy pharmacist for an initial consultation and then every 3 months (M3, 6,9, 12) and then at 18 months
Having been previously explored according to good practice and informed
Having signed the informed consent

Exclusion Criteria

Pregnant or breastfeeding women
Severe visceral deficiencies in the previous year
Individualised psychiatric pathology
Other progressive infectious pathologies requiring antibiotic treatment
Taking anticoagulants
Concomitant intake of non-drug treatments
Clear my responses

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