Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane

  • STATUS
    Recruiting
  • End date
    Jun 14, 2023
  • participants needed
    25
  • sponsor
    University of Arkansas
Updated on 14 June 2021

Summary

The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.

Description

This is a study on volunteers to determine effective dose of dexrazoxane in degrading Topoisomerase 2 b in human blood samples. Each participant will receive one dose of dexrazoxane. Blood samples will be collected to determine the time course and degradation of Topoisomerase 2b and Topoisomerase 2a

Details
Condition healthy
Treatment Dexrazoxane
Clinical Study IdentifierNCT03930680
SponsorUniversity of Arkansas
Last Modified on14 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women
Age 18-65
Not pregnant, Not currently breast feeding
No current illness
Not on prescribed medication,or nutritional supplement

Exclusion Criteria

Pregnancy, currently breast feeding
Current illness
On prescribed medication or nutritional supplement
History of cardiac, or renal disease
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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