Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

  • STATUS
    Recruiting
  • End date
    Apr 1, 2025
  • participants needed
    538
  • sponsor
    The Netherlands Cancer Institute
Updated on 12 June 2021
cancer chemotherapy
fallopian tube
cytoreductive surgery
intraperitoneal chemotherapy
ovarian epithelial carcinoma
cancer of the ovary

Summary

stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy

Description

The objective of this study is to prove that treatment with primary cytoreductive surgery in combination with HIPEC (treatment arm) improves outcome compared to primary cytoreductive surgery without HIPEC (standard arm) with acceptable morbidity, in patients with FIGO stage III epithelial ovarian cancer who are eligible for primary cytoreductive surgery with no residual disease, or residual disease up to 2.5 mm.

Details
Condition Ovarian disorder, Ovarian Cancer, ovarian carcinomas, cancer, ovarian, cancer ovarian, cancer of the ovary, ovarian tumors
Treatment cisplatin
Clinical Study IdentifierNCT03772028
SponsorThe Netherlands Cancer Institute
Last Modified on12 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

candidate for primary CRS
histological or cytological proven FIGO stage III primary epithelial ovarian, fallopian tube, or extra-ovarian cancer

Exclusion Criteria

history of previous malignancies within 5 years prior to inclusion
FIGO stage IV disease
complete primary cytoreduction is impossible
prior treatment for the current malignancy
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