Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) (OVHIPEC-2)

  • End date
    Apr 1, 2026
  • participants needed
  • sponsor
    The Netherlands Cancer Institute
Updated on 5 June 2022
cancer chemotherapy
fallopian tube
cytoreductive surgery
intraperitoneal chemotherapy
ovarian epithelial carcinoma
cancer of the ovary


stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy


The objective of this study is to prove that treatment with primary cytoreductive surgery in combination with HIPEC (treatment arm) improves outcome compared to primary cytoreductive surgery without HIPEC (standard arm) with acceptable morbidity, in patients with FIGO stage III epithelial ovarian cancer who are eligible for primary cytoreductive surgery with no residual disease, or residual disease up to 2.5 mm.

Condition Ovarian Cancer
Treatment cisplatin
Clinical Study IdentifierNCT03772028
SponsorThe Netherlands Cancer Institute
Last Modified on5 June 2022


Yes No Not Sure

Inclusion Criteria

candidate for primary CRS
histological or cytological proven FIGO stage III primary epithelial ovarian, fallopian tube, or extra-ovarian cancer

Exclusion Criteria

history of previous malignancies within 5 years prior to inclusion
FIGO stage IV disease
complete primary cytoreduction is impossible
prior treatment for the current malignancy
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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