The Effectiveness of YAG Iridotomy in Preventing Peripheral Anterior Synechia After CLASS in Primary Open Angle Glaucoma

  • End date
    Aug 14, 2023
  • participants needed
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 14 June 2021
brimonidine tartrate ophthalmic solution
intraocular pressure
primary open angle glaucoma
hypotensive agents


To investigate the effectiveness of YAG laser iridotomy in preventing peripheral anterior synechia after CO2 Laser-Assisted Sclerectomy Surgery and the long-term effect of reducing intraocular pressure


Group A: YAG laser iridotomy was performed one week before operation, followed by CO2 Laser-Assisted Sclerectomy Surgery; Group B: only CO2 Laser-Assisted Sclerectomy Surgery; The patients were followed up for 1 year to observe and compare the difference of the incidence of peripheral anterior synechia and the effect of long-term intraocular pressure control between the two groups.

Condition Pigmentary glaucoma, Open Angle Glaucoma
Treatment YAG iridotomy
Clinical Study IdentifierNCT04912362
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on14 June 2021


Yes No Not Sure

Inclusion Criteria

Primary open angle glaucoma patients in Ophthalmic Center
Topical use of hypotensive drugs in the treatment of poor or intolerable intraocular pressure control
The patients were 18 to 50 years old, regardless of gender
Class operation was performed
Patients are able and willing to comply with the research guidance and may complete all visits required by the research
Informed consent has been signed

Exclusion Criteria

Allergic to any perioperative medication in this study
History of ocular trauma
Any previous intraocular surgery
Gonioscopy showed a narrow angle (Schaffer III or below)
Secondary glaucoma was diagnosed
Optic atrophy caused by other reasons
Severe complications such as rupture of posterior capsule and choroidal hemorrhage occurred during operation
Patients with severe ocular complications after operation
The patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney
Women in pregnancy, lactation or planned pregnancy
The researchers believe that the patient's condition may put the patient at significant risk, may confuse the results of the study, or may significantly interfere with the patient's participation in the study
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