Angiotensin Receptor Blockers in Aortic Stenosis (ARBAS)
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- STATUS
- Recruiting
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- End date
- Feb 21, 2025
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- participants needed
- 144
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- sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Summary
This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.
Description
Studies support the concept that activation of the renin-angiotensin system may be involved in the progression of valve stenosis and myocardial fibrosis in aortic stenosis. Furthermore recent studies have shown that renin-angiotensin system medication may slow down aortic stenosis progression rate and left ventricle remodeling.
Thus the present study is a randomized control trial to test the efficacy of the angiotensin receptor blocker (ARB) to slow down aortic stenosis progression and left ventricular remodeling/dysfunction in patients with mild-to-moderate aortic stenosis.
Details
| Condition | Aortic Stenosis |
|---|---|
| Treatment | Placebo, Angiotensin Receptor Blockers |
| Clinical Study Identifier | NCT04913870 |
| Sponsor | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval |
| Last Modified on | 21 April 2022 |
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