A Clinical Study Preliminary Efficacy of LM-061 Tablet in Subjects With Advanced Tumours

  • STATUS
    Recruiting
  • End date
    Aug 30, 2024
  • participants needed
    87
  • sponsor
    LaNova Medicines Limited
Updated on 7 June 2021

Summary

This is a phase I/II, open-label, dose escalation and dose extension study to evaluate the safety, tolerability, PK, and preliminary efficacy of LM-061 in subjects with advanced tumors.

Description

This is a phase I/II, open-label, dose escalation and dose extension study to evaluate the safety, tolerability, PK, and preliminary efficacy of LM-061 in subjects with advanced tumors.

The study schedule includes screening visit (28 days prior to accept the investigational medicinal product (IMP)), treatment visit (accept IMP for the first time to the end of treatment (EOT)/early withdrawal), and follow-up visit (28 days after the EOT/early withdrawal).

Details
Condition Advanced Tumours
Treatment LM-061
Clinical Study IdentifierNCT04882176
SponsorLaNova Medicines Limited
Last Modified on7 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Volunteer to participate in clinical study, sign a written informed consent form, and be able to comply with clinical visits and study related procedures
Male or female subjects 18 to 75 years old (both inclusive) when sign the informed consent
Study population
Dose Escalation the subjects with advanced malignant tumors confirmed by histology or cytology, and have failed standard treatment, or have no standard treatment, or not suitable for standard treatment at present
Dose Extension patients with advanced solid tumors with abnormal c-Met, including EGFR-TKI-resistant non-small cell lung cancer and pulmonary sarcomatoid adenocarcinoma, diagnosed histologically or cytologically, who have failed standard therapy, or who do not have standard treatment regimens, or who are not suitable for standard therapy at this stage;Papillary renal cell carcinoma;Metastatic or locally advanced unresectable gastric adenocarcinoma with at least first-line standard treatment
ECOG score 0-1
C-MET abnormalities are defined by central laboratory as the situation that meets one of the following: Abnormal expression of c-Met immunohistochemistry (IHC) : strong staining (2+ or above) in more than 50% of tumor cells; MET amplification positive: MET/CEP 7 2 or GCN 5; MET exon14-skipping mutation
The estimated survival time is not less than 3 months
The functional of bone marrow reserve and organs must meet the following requirements (without ongoing continuous supportive treatment): Bone marrow reserve: Neutrophil count (NE#) 1.5109/L, platelet count (PLT) 90 109/L; hemoglobin (HGB) > 9.0 g/dL (no blood transfusion or hematopoietic stimulating factor therapy within 14 days); Coagulation function: activated partial thromboplastin time (APTT) prolong 1.5 upper limit of normal (ULN), and international standard ratio (INR) 1.5; Liver function: total bilirubin (TBIL) 1.5ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 2.5ULN (if there is liver metastasis, ALT or AST 5ULN); Kidney function: Creatinine clearance rate 50 mL/min (using Cockcroft-Gault formula, see Appendix 1) or serum creatinine 1.5ULN; qualitative urine protein 1+ or qualitative urine protein 2+, but 24-hour urine protein <1g; Cardiac function: left ventricular ejection fraction (LVEF) 50%; ECG is basically normal, and corrected QT interval (QTcF) 450 ms and 470 ms for male and female, respectively
According to RECIST v1.1 criteria, there should be at least one evaluable tumor focus in the dose escalation phase;At least one measurable tumor was present during the dose expansion phase
Eligible subjects with fertility (male and female) must agree to use reliable contraceptive methods (hormonal or barrier method or abstinence, etc.) with their partners during the trial period and at least 3 months after the last administration; women of childbearing age (Refer to Appendix 2 for definitions) The subject's serum pregnancy test must be negative within 7 days prior to the first administration

Exclusion Criteria

Have received chemotherapy, radiotherapy, biological therapy, endocrine therapy, immune checkpoint inhibitor therapy and other anti-tumour treatments within 4 weeks prior to first dose of IMP, except for the following items
Subjects was diagnosed as acute promyelocytic leukemia (APL), breakpoint cluster region-abelson (BCR-ABL)-positive leukemia (i.e., chronic myelogenous leukemia in blast crisis), active central nervous system leukemia, or AML secondary to prior chemotherapy for other neoplasms
Have used nitrosourea or Mitomycin C within 6 weeks prior to first dose of IMP
Have used oral fluorouracil and small molecule targeted drugs within 2 weeks or 5 half-lives of the drugs prior to first dose of IMP (whichever is longer)
Have received other unmarketed clinical study drugs or treatments within 4 weeks prior to first dose of IMP
Have undergone major organ surgery (excluding biopsy) or have had significant trauma or invasive dental procedures (such as tooth extraction, dental implant) within 4 weeks prior to first dose of IMP, or required elective surgery during the study period
Have serious unhealable wounds/ulcers/bone fractures within 4 weeks prior to first dose of IMP
Are taking (or cannot be stopped at least 1 week prior to first dose of IMP) any drug that is known to strongly inhibit or induce CYP3A4 (see Appendix 5 for details)
The histopathological type of the tumour is head and neck or lung squamous cell carcinoma, or other tumours with bleeding tendency as judged by the investigator
Bleeding events of grade 3 or above occurred within 6 months before the first dose of IMP or currently grade 2 bleeding or factors judged by the investigator to have a high risk of bleeding (such as active peptic ulcer or esophageal varices) at present
The adverse reactions of previous anti-tumour treatments have not yet recovered to CTCAE 5.0 grade evaluation 1 (except for toxicity judged by the investigator to have no safety risk, such as hair loss, grade 2 peripheral neurotoxicity, etc.)
Central nervous system metastasis or meningeal metastasis with clinical symptoms, or other evidence that the subject's central nervous system metastasis or meningeal metastasis has not been controlled, and the investigator judges it to be unsuitable for inclusion
Gastrointestinal perforation, abdominal fistula, or intra-abdominal abscess occurred within 6 months before the first dose of the IMP; or the investigator has determined that there are high-risk factors for the formation of cavity organ perforation/fistula (such as tumour infiltration in the cavity Outer layer of the wall); inflammatory bowel disease (including ulcerative colitis and Crohn's disease), diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis
Unable to be dosed orally, or there are conditions that have been judged by the investigators to seriously affect the absorption of the gastrointestinal tract, such as dysphagia, nausea and vomiting that are difficult to control, intestinal obstruction, and gastric outlet obstruction
Have active infection 1 week before the first dose of IMP and currently need systemic anti-infective treatment
HIV infection, active HBV infection (HBV DNA exceeds the ULN), active HCV infection (HCV RNA exceeds the ULN)
Have a history of serious cardiovascular and cerebrovascular diseases, including but not limited to: Severe heart rhythm or conduction abnormalities, such as ventricular arrhythmia that requires clinical intervention, grade - atrioventricular block, etc.; Thromboembolic events requiring therapeutic anticoagulation, or subjects with venous filters;According to the New York Heart Association (NYHA) standards, subjects with grade III~IV cardiac insufficiency;Acute coronary syndrome, congestive heart failure, aortic dissection, stroke or other cardiovascular and cerebrovascular events of grade 3 or above occurred within 6 months before the first administration of IMP;Clinically uncontrollable hypertension (blood pressure cannot be controlled at systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg after standard antihypertensive treatment);Any factors that increase the risk of QTc prolongation or arrhythmia, such as heart failure, hypokalemia, congenital long QT syndrome, use of any concomitant drugs that are known or may prolong the QT interval (see Appendix 5 for details)
The third gap effusion that cannot be controlled clinically is not suitable for inclusion in the study judged by the investigator
Known history of drug abuse
Subjects with mental disorders or poor compliance
Women who are pregnant or breastfeeding
Cannot tolerate venous blood sampling
Known to be allergic to LM-061 tablets or any of its excipients
Has history of other serious systemic diseases judged by the investigator, or other reasons are not suitable for participating in the study
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