Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

  • End date
    May 15, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 6 June 2021
heart failure
rehabilitation program


This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulmonary hypertension caused by heart failure.


The purpose of this research is to see if taking part in structured exercise training will improve the ability to exercise, the function of the heart, and the function of the blood vessels that supply the lungs in patients with heart failure and pulmonary hypertension. After enrollment all patients will complete exercise testing. Patients will be randomized to either 10 weeks of exercise training (3 times per week) or will continue standard medical care. All patients will undergo detailed exercise testing before and after the intervention.

Condition Heart failure, Heart disease, Pulmonary Hypertension, Congestive Heart Failure, cardiac failure, congestive heart disease
Treatment exercise training
Clinical Study IdentifierNCT04909008
SponsorMayo Clinic
Last Modified on6 June 2021


Yes No Not Sure

Inclusion Criteria

NYHA functional class I-IIIb
LVEF < 40%
Clinically-stable for > 3 months [no change in disease status or medication]
Willing and able to provide written informed consent and perform cycle-ergometer or treadmill based exercise

Exclusion Criteria

NYHA class IV HF
Diagnosis of diastolic HF
Comorbidities such as obesity (BMI >36), uncontrolled systemic hypertension, type 2 diabetes, and COPD (FEV1 <50%)
Musculoskeletal or other conditions that would limit exercise participation
Pregnant or nursing women
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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