Study of Carfilzomib Lenalidomide Dexamethasone and Belantamab Mafodotin in Multiple Myeloma

  • End date
    Oct 3, 2024
  • participants needed
  • sponsor
    Shebli Atrash
Updated on 3 June 2021
chemotherapy regimen


This research study is being done to learn if the study drug belantamab mafodotin, in combination with other standard medications, can improve multiple myeloma. This study will also help determine what effects, good and/or bad, this combination of study drugs have on subjects and their cancer, and to evaluate the overall response to this study treatment combination.


This is a phase I dose escalation and expansion study in RMM and RRMM followed by a single arm phase II expansion in high risk, NDMM. The phase I portion of the protocol will utilize a standard 3+3 dose escalation design to determine the maximum tolerated dose (MTD) and RP2D of the KRd-belantamab mafodotin combination. The phase II portion of the trial is a two-stage design that will assess the efficacy and safety of the combination in newly diagnosed, high-risk MM patients.

Condition Multiple Myeloma, Lymphoproliferative Disorder, multiple myeloma (mm)
Treatment Carfilzomib, Lenalidomide, Dexamethasone, Belantamab Mafodotin
Clinical Study IdentifierNCT04822337
SponsorShebli Atrash
Last Modified on3 June 2021


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