Efficacy and Safety of Vonoprazan as First-line Treatment for Helicobacter Pylori Eradication

  • STATUS
    Recruiting
  • participants needed
    234
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 29 May 2022

Summary

This study aims to evaluate the efficacy of vonoprazan compared with esomeprazole as first-line treatment for Helicobacter Pylori(Hp) eradication, as well as the safety and economic benefits.

Description

Vonoprazan, a novel potassium-competitive acid blocker, is proved to be superior to proton pump inhibitor in gastric acid-related diseases such as reflux esophagitis, as the increase of intragastric pH maintains for a longer period. Vonoprazan, therefore, is a promising candidate in helicobacter pylori eradication as the antibiotic resistance is rising.

This study will enroll 234 patients, and randomly assigned by computer to one of the three treatment groups.

Group A: Vonoprazan taken with bismuth, amoxicillin, furazolidone for 10 days Group B: Vonoprazan taken with bismuth, amoxicillin, furazolidone for 14 days Group C: Esomeprazole taken with bismuth, amoxicillin, furazolidone for 14 days Participants will visit the clinic for a follow-up assessment 6-8 weeks after the course of treatments.

Details
Condition Helicobacter Pylori Infection, H. Pylori Infection
Treatment Esomeprazole, Amoxicillin, Vonoprazan, Furazolidone, Colloidal bismuth pectin
Clinical Study IdentifierNCT04907747
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on29 May 2022

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