Blood Markers for Identifying & Investigating Infection With COVID19 & Sepsis in Children.

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    300
  • sponsor
    Cardiff University
Updated on 2 June 2021
acute illness

Summary

Corona Virus Disease or COVID-19 is caused by SARS-CoV-2 virus. There have been reports of serious COVID-19 illness in children. In addition it has been linked to clusters of children presenting with high fevers and inflammation.

Sepsis, also called blood poisoning, is an abnormal response of the body to some infections. We aim to conduct research in children under 18 admitted to intensive care unit.

Using a systems approach towards mapping the body's immune and metabolic responses to COVID-19 or related illnesses and compare with other sepsis like illnesses.

Description

Corona Virus Disease or COVID-19 is caused by SARS-CoV-2 virus. There have been reports of serious COVID-19 illness in children. In addition it has been linked to clusters of children presenting with high fevers and inflammation.

Sepsis, also called blood poisoning, is an abnormal response of the body to some infections. We aim to conduct research in children under 18 admitted to intensive care unit and wards using blood samples. Blood samples as small as a quarter of a teaspoon, will be collected only alongside other routine blood tests. By analysing the blood samples, we aim to identify unique signals of information from the child or young person's genetic code as well as other chemical markers. This is to map the body's immune and metabolic response to COVID-19 or related illness and compare with other illnesses like sepsis. It will help us better understand COVID-19 illness and its association with the abnormal inflammatory response. The research will not delay emergency treatment for children or young people. Appropriate procedures for consent such as deferred consent will be used in children or young people with serious illness. Young people of 16 and 17 years of age will be assessed for capacity to consent. The study results will not influence the clinical care of patients. The research would not be identifying any other genetic disorders. Even though the data obtained includes some unique genetic information, the research only uses anonymised details from patients and there is no risk to confidentiality. Remaining blood following analysis will be stored in Biobank for an agreed duration. Specific consent will be obtained from parents or legal guardians, or young people with capacity for analysis and collection of unique genetic data, clinical information, sample storage and use of anonymous but unique genetic data for other research.

Details
Condition systemic infection, sepsis syndrome, systemic infections, Septicemia, COVID19, Sepsis and Septicemia, sepsis
Treatment Diagnostic Test:Blood test
Clinical Study IdentifierNCT04904523
SponsorCardiff University
Last Modified on2 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Children or young people< 18 years who are admitted to
PCCU and who have an acute illness are eligible for participation in the
study
Children and young people from age 0 day to <18 years with confirmed COVID-19
illness and/or those who meet the Multisystem inflammatory syndrome case
definition
\-

Exclusion Criteria

Admitted to hospital for social reasons Or Declined consent by Parents or carers with legal responsibility or competent child Or Admitted to PCCU following a planned surgical procedure without an acute illness Or Direct clinical care team not able to provide research information in a language appropriate for non-English/Welsh speaking participants
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